Journal of Pathology and Translational Medicine

Case Studies

Mucocele of the rectal stump: mucinous cystic neoplasm with low-grade dysplasia simulating low-grade appendiceal mucinous neoplasm: Hasan Basri Aydin, Maria Faraz, A. David Chismark, Haiyan Qiu, Hwajeong Lee; J Pathol Transl Med. 2025;59(2):139-146. Published online February 26, 2025; DOI: https://doi.org/10.4132/jptm.2024.12.27

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Abstract PDF: Mucoceles, commonly observed in the appendix, are mucin-filled, dilated structures arising from a range of etiologies. Cases associated with dysplastic or neoplastic epithelium can rupture and disseminate within the abdominopelvic cavity. Similar lesions in other parts of the colon are exceedingly rare, with only 16 colonic mucoceles having been reported. The first case of a colonic mucinous neoplasm with dysplasia resembling a low-grade appendiceal mucinous neoplasm involving rectal stump was described in 2016. Here, we present the second such case arising in the rectal stump, identified in a 44-year-old male with extensive surgical history. Microscopic examination revealed low-grade dysplastic epithelium lining the cyst and mucin dissecting into the stroma, without evidence of rupture or extramural mucin. The patient was followed for 16 months without recurrence or peritoneal disease. The exact etiology and outcome of these rare lesions remain unknown, requiring close follow-up.

Coexisting Mucinous Cystic Neoplasm of the Pancreas and Type 1 Autoimmune Pancreatitis: Mee-Jeong Kim, Tae Jun Song, Hyoung Jung Kim, Song-Cheol Kim, Myung-Hwan Kim, Seung-Mo Hong; J Pathol Transl Med. 2019;53(2):125-128. Published online November 14, 2018; DOI: https://doi.org/10.4132/jptm.2018.10.25

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Type 1 autoimmune pancreatitis (AIP1) is an IgG4-related systemic disease that mimics tumors. We report a rare case of AIP1 accompanied by mucinous cystic neoplasm (MCN). A pancreatic lesion was incidentally detected in a woman in her 60s. After 6 years of follow-up, the lesion abruptly increased in size. Computed tomography showed a 3.5 cm unilocular cyst in the tail of the pancreas and distal pancreatectomy was performed. On microscopic examination, the cyst was lined by mucinous and non-mucinous epithelial cells with mild cytologic atypia. The surrounding stroma comprised ovarian-type spindle cells with progesterone receptor positivity. The pericystic pancreas exhibited multifocal lymphoid follicles, lymphoplasmacytic infiltrations, obliterative phlebitis, and storiform fibrosis. IgG4-positive plasma cell infiltration (215 cells high-power field) and the IgG4/IgG ratio (57%) were increased. Cases of MCN coexisting with AIP1 are extremely rare; only two such cases have been reported in the English-language literature. This third case featured low-grade MCN with AIP1.

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Utilizing Immunoglobulin G4 Immunohistochemistry for Risk Stratification in Patients with Papillary Thyroid Carcinoma Associated with Hashimoto Thyroiditis
Faridul Haq, Gyeongsin Park, Sora Jeon, Mitsuyoshi Hirokawa, Chan Kwon Jung
Endocrinology and Metabolism.2024; 39(3): 468. CrossRef
Histological features of autoimmune pancreatitis and IgG4-related sclerosing cholangitis with a correlation with imaging findings
Kenji NOTOHARA
Choonpa Igaku.2023; 50(1): 55. CrossRef
Imaging Features and Risk Factors of Pancreatic Cystic Lesions Complicating Autoimmune Pancreatitis: A Retrospective Study
Bin-Bin Zhang, Xin-Meng Hou, Yu-Qi Chen, Jian-Wei Huo, Er-Hu Jin
Current Medical Imaging Formerly Current Medical Imaging Reviews.2023;[Epub] CrossRef
Histological features of autoimmune pancreatitis and IgG4-related sclerosing cholangitis with a correlation with imaging findings
Kenji Notohara
Journal of Medical Ultrasonics.2021; 48(4): 581. CrossRef
自己免疫性膵炎診療ガイドライン2020

Suizo.2020; 35(6): 465. CrossRef
Mucinous cystic neoplasm of the pancreas with type-1 autoimmune pancreatitis-like lesion
Kevin Gowing, David F. Schaeffer, Hui-Min Yang
Human Pathology: Case Reports.2019; 18: 200339. CrossRef

Metaplastic Carcinoma with Chondroid Differentiation Arising in Microglandular Adenosis: Ga-Eon Kim, Nah Ihm Kim, Ji Shin Lee, Min Ho Park; J Pathol Transl Med. 2017;51(4):418-421. Published online April 4, 2017; DOI: https://doi.org/10.4132/jptm.2016.10.06

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Microglandular adenosis (MGA) of the breast is a rare, benign proliferative lesion but with a significant rate of associated carcinoma. Herein, we report an unusual case of metaplastic carcinoma with chondroid differentiation associated with typical MGA. Histologically, MGA showed a direct transition to metaplastic carcinoma without an intervening atypical MGA or ductal carcinoma in situ component. The immunohistochemical profile of the metaplastic carcinoma was mostly similar to that of MGA. In both areas, all the epithelial cells were positive for S-100 protein, but negative for estrogen receptor, progesterone receptor, HER2/neu, and epidermal growth factor receptor. An increase in the Ki-67 and p53 labelling index was observed from MGA to invasive carcinoma. To the best of our knowledge, this is the first case of metaplastic carcinoma with chondroid differentiation arising in MGA in Korea. This case supports the hypothesis that a subset of MGA may be a non-obligate morphologic precursor of breast carcinoma, especially the triple-negative subtype.

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Elucidating the nature of acinic cell carcinoma of the breast with high-grade morphology: evidence from case report
Yunjie Ge, Xianping Wei, Jing-Nan Liu, Ping-Li Sun, Hongwen Gao
Diagnostic Pathology.2024;[Epub] CrossRef
New insights into acinic cell carcinoma of the breast: clinicopathology, origin of histology, molecular features, prognosis, and treatment
Yunjie Ge, Xianping Wei, Jing-Nan Liu, Ping-Li Sun, Hongwen Gao
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Metaplastic Matrix-Producing Carcinoma and Apocrine Lobular Carcinoma In Situ Associated with Microglandular Adenosis: A Unique Case Report
Nektarios Koufopoulos, Dionysios Dimas, Foteini Antoniadou, Kyparissia Sitara, Dimitrios Balalis, Ioannis Boutas, Alina Roxana Gouloumis, Adamantia Kontogeorgi, Lubna Khaldi
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Salivary gland-type mammary carcinoma arising in microglandular adenosis: A case report and clinicopathological review of the literature
Victoria Rico, Yukiko Shibahara, Marjorie Monteiro, Elzbieta Slodkowska, Samantha Tam, Pearl Zaki, Carlo De Angelis, Edward Chow, Katarzyna Joanna Jerzak
Cancer Treatment and Research Communications.2020; 24: 100178. CrossRef
Microglandular adenosis is an advanced precursor breast lesion with evidence of molecular progression to matrix-producing metaplastic carcinoma
Christopher J. Schwartz, Igor Dolgalev, Esther Yoon, Iman Osman, Adriana Heguy, Eleazar C. Vega-Saenz de Miera, Diana Nimeh, George Jour, Farbod Darvishian
Human Pathology.2019; 85: 65. CrossRef

Original Articles

Comprehensive Cytomorphologic Analysis of Pulmonary Adenoid Cystic Carcinoma: Comparison to Small Cell Carcinoma and Non-pulmonary Adenoid Cystic Carcinoma: Seokhwi Kim, Jinah Chu, Hojoong Kim, Joungho Han; J Pathol Transl Med. 2015;49(6):511-519. Published online October 19, 2015; DOI: https://doi.org/10.4132/jptm.2015.09.07

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Background
Cytologic diagnosis of pulmonary adenoid cystic carcinoma (AdCC) is frequently challenging and differential diagnosis with small cell carcinoma is often difficult. Methods: Eleven cytologically diagnosed cases of pulmonary AdCC were collected and reviewed according to fifteen cytomorphologic characteristics: small cell size, cellular uniformity, coarse chromatin, hyperchromasia, distinct nucleolus, frequent nuclear molding, granular cytoplasm, organoid cluster, sheet formation, irregular border of cluster, hyaline globule, hyaline basement membrane material, individual cell necrosis or apoptotic body, and necrotic background. Twenty cases of small cell carcinoma and fifteen cases of non-pulmonary AdCC were also reviewed for the comparison. Results: Statistically significant differences were identified between pulmonary AdCC and small cell carcinoma in fourteen of the fifteen cytomorphologic criteria (differences in sheet formation were not statistically significant). Cellular uniformity, distinct nucleolus, granular cytoplasm, distinct cell border, organoid cluster, hyaline globule, and hyaline basement membrane material were characteristic features of AdCC. Frequent nuclear molding, individual cell necrosis, and necrotic background were almost exclusively identified in small cell carcinoma. Although coarse chromatin and irregular cluster border were observed in both, they favored the diagnosis of small cell carcinoma. Hyaline globules were more frequently seen in non-pulmonary AdCC cases. Conclusions: Using the fifteen cytomorphologic criteria described by this study, pulmonary AdCC could be successfully distinguished from small cell carcinoma. Such a comprehensive approach to an individual case is recommended for the cytologic diagnosis of pulmonary AdCC.

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Primary pulmonary adenoid cystic carcinoma: A study of clinicopathological features and molecular alterations in twenty-one cases
Zhiyuan Yao, Tong Qiu, Changlei Li, Weimao Kong, Guangqi Li, Peng Song, Guohua Wang, Wenjie Jiao
Lung Cancer.2025; 201: 108414. CrossRef
Recent developments in the pathology of primary pulmonary salivary gland‐type tumours
Julia R Naso, Anja C Roden
Histopathology.2024; 84(1): 102. CrossRef
Bronchial cytology of pulmonary adenoid cystic carcinoma – A multi-institute series with emphasis on immunocytochemistry
Joanna K.M. Ng, Ka Pang Chan, Gary M. Tse, Joshua J.X. Li
Annals of Diagnostic Pathology.2023; 64: 152132. CrossRef
Pulmonary adenoid cystic carcinoma: molecular characteristics and literature review
Zhixin Chen, Jiapeng Jiang, Ying Fan, Hongyang Lu
Diagnostic Pathology.2023;[Epub] CrossRef
Recent updates in salivary gland tumors of the lung
Anja C. Roden
Seminars in Diagnostic Pathology.2021; 38(5): 98. CrossRef
Cytology of Primary Salivary Gland-Type Tumors of the Lower Respiratory Tract: Report of 15 Cases and Review of the Literature
Chiara Saglietti, Marco Volante, Stefano La Rosa, Igor Letovanec, Marc Pusztaszeri, Gaia Gatti, Massimo Bongiovanni
Frontiers in Medicine.2017;[Epub] CrossRef

Comparison of Cytologic Characteristics between Adenoid Cystic Carcinoma and Adenoid Basal Carcinoma in the Uterine Cervix: Juhyeon Jeong, Seung Yeon Ha, Hyun Yee Cho, Dong Hae Chung, Jungsuk An; J Pathol Transl Med. 2015;49(5):396-402. Published online August 17, 2015; DOI: https://doi.org/10.4132/jptm.2015.07.08

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Background
Adenoid cystic carcinoma (ACC) and adenoid basal carcinoma (ABC) are rare in the uterine cervix. ACC is more aggressive than ABC, thus accurate differential diagnosis is important. In this study, we identified cytologic features useful in distinguishing these two tumors for diagnosis. Methods: Three cases of ACC and five cases of ABC were selected for this study. Cervicovaginal smear slides were reviewed retrospectively, and the area, circumference, major axis, and minor axis of nuclei were measured using an image analyzer. Results: ACC displayed three-dimensional clusters with a small acini pattern. ABC displayed peripheral palisading without an acini pattern. The nuclei of ACC were more irregular and angulated than those of ABC, and the former showed a coarsely granular chromatin pattern. The nucleic area, circumference, major axis, and minor axis were 18.556±8.665 µm², 23.320±11.412 µm, 5.664±1.537 µm, and 4.127±1.107 µm in ACC and 11.017±4.440 µm², 15.920±5.664 µm, 4.612±1.025 µm, and 3.088±0.762 µm in the cases of ABC. All measured values showed statistically significant difference (p < .001). Conclusions: Although the nuclei of both of these tumor types were oval shaped, inferred from the ratio of minor axis to major axis (0.728 in ACC and 0.669 in ABC), the area of nuclei was approximately 1.7 times larger in ACC than in ABC. Distinguishing nucleic features, including area, morphology, and chromatin pattern, may be helpful in making a correct diagnosis.

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Adenoid basal carcinoma of the uterine cervix
Anas Mohamed, Tesfalem Korga, Ahlam Ali, Javier Laurini
International Journal of Gynecological Cancer.2025; : 101873. CrossRef
Adenoid Basal Carcinoma of the Uterine Cervix: A Case Report
Tatsuya Kanuma, Keiko Kigure, Tosio Nishimura, Yuji Ibuki, Shigeru Tsuchida, Harumi Kamiyama, Misa Iijima, Kazuto Nakamura
The KITAKANTO Medical Journal.2016; 66(1): 11. CrossRef

Brief Case Reports

Digital Papillary Carcinoma: Sharon Lim, Inju Cho, Mi Ja Lee; Korean J Pathol. 2014;48(6):438-441. Published online December 31, 2014; DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.6.438

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Digital Papillary Adenocarcinoma: Uncommon Malignancy of Sweat Glands - Two Rare Cases
Neeti Goyal, Pawan Dhaman, Jasvinder Kaur Bhatia, Pragya Sharma, Prabha Shankar Mishra, Vikram Singh, Anvesh Rathore
Journal of Marine Medical Society.2025; 27(1): 103. CrossRef
Digital papillary adenocarcinoma: A case report of a rare malignant tumour with recommendations on management and follow-up
Varanindu Mudduwa, Mohammad Goodarzi, Richard Chalmers, Haitham Khashaba
International Journal of Surgery Case Reports.2025; 127: 110922. CrossRef
Digital papillary adenocarcinoma: A case report
Betty A. Kasimo, Vivian Akello, James J. Yahaya
Clinical Case Reports.2021;[Epub] CrossRef
A rare case of a digital papillary carcinoma of the hand with secondary conservative management
Rabeet Khan, Renu Irri, Effie Katsarma
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Cytokeratin-Positive Gastrointestinal Stromal Tumor of Biphasic Morphology: A Case Report: Sung Sun Kim, Yoo Duk Choi, Jae Hyuk Lee, Chan Choi; Korean J Pathol. 2014;48(5):375-378. Published online October 27, 2014; DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.5.375

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CYTOKERATINS: NOT AN EPITHELIAL ENTITY ANYMORE?
Geetpriya Kaur, Devicharan Shetty, Seema Sikka, Aparna Pathak
INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH.2022; : 15. CrossRef
Gastrointestinal stromal tumors of the stomach in a 10-year-old child
Saeed Nasher, Fayed Al-Yousofy, Faisal Ahmed
Journal of Pediatric Surgery Case Reports.2021; 74: 102044. CrossRef

Case Study

Sebaceous Carcinoma Arising in Mature Cystic Teratoma of Ovary: Hyo Jeong An, Yong Han Jung, Hye Kyoung Yoon, Soo Jin Jung; Korean J Pathol. 2013;47(4):383-387. Published online August 26, 2013; DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.4.383

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Abstract PDF

Roughly 1% of mature cystic teratomas undergo malignant transformation. In particular, cutaneous-type adnexal neoplasms may occur in mature cystic teratomas. Sebaceous carcinomas, which arise from mature cystic teratomas, have rarely been observed, with only seven cases previously reported. Here, we present a case of a 69-year-old female who had pelvic pain for two weeks and who subsequently underwent bilateral salpingo-oophorectomy and hysterectomy. Her left ovary showed a unilocular cyst, measuring 22.0 cm in diameter, filled with sebaceous material and a few hairs. A luminally-protruding solid mass measuring 4.0 cm in diameter was also noted. Microscopic findings revealed lobular or diffusely arranged basophilic, atypical sebaceous cells connected to a typical mature cystic teratoma. Tumor cells demonstrated positive immunoreactivity for high molecular weight cytokeratin, cytokeratin 7, cytokeratin 19, epithelial membrane antigen, and carcinoembryonic antigen. Here, we present a case of sebaceous carcinoma arising from a mature cystic teratoma along with a review of previously published reports.

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How can we best manage ovarian sebaceous carcinomas arising from mature cystic teratomas?
Hong Min Shaye Peng, Sung Hock Chew, Yang Huang Grace Ng, Felicia Hui Xian Chin
BMJ Case Reports.2025; 18(2): e264651. CrossRef
Genetic Profiling of Sebaceous Carcinoma Arising from an Ovarian Mature Teratoma: A Case Report
Sumika Zaitsu, Yoko Aoyagi, Haruto Nishida, Kohei Nakamura, Mitsutake Yano, Eiji Kobayashi
International Journal of Molecular Sciences.2024; 25(12): 6351. CrossRef
Extraocular sebaceous carcinoma arising in a mature cystic teratoma of ovary: A case report and review of literature
Sara Pakbaz, Tanya Chawla, Marcus Q Bernardini, Liat Hogen, Marjan Rouzbahman
Human Pathology Reports.2022; 27: 300592. CrossRef
Sebaceous adenoma occurring within an intracranial dermoid cyst
Takashi Minamisaka, Johji Imura, Keitaro Shiraishi, Kohji Takagi, Takahiko Tomia, Sinichi Tanaka, Akira Noguchi, Takuya Akai, Kyo Noguchi, Satoshi Kuroda
Neuropathology.2022; 42(4): 289. CrossRef
Malignant transformation of mature cystic teratoma of the ovary
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Sebaceous Carcinoma Arising in Ovarian Teratoma: First Report Associated With Germline Mismatch Repair Gene Mutation
Jacinta Murray, Patrick McIlwaine, Patrick J. Morrison, W. Glenn McCluggage
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Impact of surgery and adjuvant treatment on the outcome of extraocular sebaceous carcinoma: a systematic review and individual patient's data analysis of 206 cases
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Pathology.2019; 51(1): 67. CrossRef
Malignant transformation of an ovary mature cystic teratoma: case report and review of the literature
Elkin Fabián Dorado-Roncancio, Oscar Joel Carrillo-Garibaldi
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A case of ovarian clear cell carcinoma arising from ovarian mature cystic teratoma
Kazuya Maeda, Yoshito Terai, Shinichi Terada, Hiroshi Maruoka, Yuhei Kogata, Keisuke Ashihara, Yoshimichi Tanaka, Tomohito Tanaka, Hiroshi Sasaki, Satoshi Tsunetoh, Takashi Yamada, Masahide Ohmichi
Journal of Ovarian Research.2018;[Epub] CrossRef
Sebaceous carcinoma arising within an ovarian mature cystic teratoma: A case report with discussion of clinical management and genetic evaluation
Alyssa Wield, Melissa Hodeib, Mohammad Khan, Lindsay Gubernick, Andrew J. Li, Shivani Kandukuri
Gynecologic Oncology Reports.2018; 26: 37. CrossRef

Case Reports

Ghost Cell Odontogenic Carcinoma Arising from Calcifying Cystic Odontogenic Tumor: A Case Report: Zhi-Yu Zhu, Zhi-Gang Chu, Yu Chen, Wei-Ping Zhang, Di Lv, Ning Geng, Ming-Zhong Yang; Korean J Pathol. 2012;46(5):478-482. Published online October 25, 2012; DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.5.478

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Abstract PDF

Ghost cell odontogenic carcinoma (GCOC) is an exceptionally rare and malignant odontogenic tumor with aggressive growth characteristics. We describe a case of GCOC which was considerably derived from a previously resected calcifying cystic odontogenic tumor (CCOT). Cellular atypia, mitotic activity, Ki-67 labeling index and matrix metalloprotease-9 positive expression rate were all increased in the currently resected specimen compared to the initial one. This is a rare case of malignant transformation of CCOT to GCOC with respect to its histopathological and immunohistochemical findings.

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Ghost Cell Odontogenic Carcinoma of the Anterior Maxilla with ARID1A Mutation: A Case Report and Literature Review
Nasser Mohammed Almadan, Doaa Alghamdi, Meshal AlOrf, Hamed Alali, Mohammed Mohajrye
Head and Neck Pathology.2025;[Epub] CrossRef
Late recurrence of calcifying odontogenic cyst: Report of a rare case and review of the literature
Paris Tamiolakis, Maria Georgaki, Panagiotis Christopoulos, Nikolaos G. Nikitakis
Oral Surgery.2024; 17(3): 258. CrossRef
Treatment challenges of persistent ghost cell odontogenic carcinoma: a case report and literature review
Ali Al-Sammak, Othman Rezki, Michael Pennington, Frances Manosca, Maria Cuevas-Nunez, Mohammed Qaisi, Even Greenbaum, James Murphy
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology.2023; 136(4): e123. CrossRef
Ghost cell odontogenic carcinoma: A rare case report and review of literature
Yong Xia, Zongchang Song, Xinlei Zhang, Xinhong Guan, Guifang Tan, Yi Le, Shuang Liu, Hui Xue, Jing Li, Yajun Zhang, Jing Chen, Huajuan Jiang, Xia Jiang, Yanxia Cheng, Chuchu Zhou, Xu Sha, Jin-Xin Lou
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A novel parotid carcinoma with a prominent ghost cell population: a masquerading tumor or “salivary ghost cell carcinoma”?
Hiroshi Harada, Mitsuo P. Sato, Naoki Otsuki, Mao Kawamura, Akira Kurose, Takao Satou
Medical Molecular Morphology.2022; 55(1): 76. CrossRef
Dentinogenic ghost cell tumor with focal atypical features suggesting ghost cell odontogenic carcinoma: Report of a challenging diagnosis
Danielle Castex Conde, Gustavo de Souza Vieira, Pâmella de Pinho Montovani, João Pedro Roque Beserra, Mauro César Gaspar Ribeiro, Rafaela Elvira Rozza-de-Menezes, Karin Soares Cunha
Oral Oncology.2022; 124: 105524. CrossRef
Comparative Analysis Between Dentinogenic Ghost Cell Tumor and Ghost Cell Odontogenic Carcinoma: A Systematic Review
Gustavo de Souza Vieira, Pâmella de Pinho Montovani, Rafaela Elvira Rozza-de-Menezes, Karin Soares Gonçalves Cunha, Danielle Castex Conde
Head and Neck Pathology.2021; 15(4): 1265. CrossRef
Ghost cell odontogenic carcinoma of anterior mandible
Gopikrishnan Vijayakumar, Mala Kamboj, Anjali Narwal, Anju Devi
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Ghost cell odontogenic carcinoma of the jaws: Report of two cases and a literature review
Meng-Qi Jia, Jun Jia, Li Wang, Hai-Xiao Zou
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Ghost cell odontogenic carcinoma with suspected cholesterol granuloma of the maxillary sinus in a patient treated with combined modality therapy
You Qin, Yanwei Lu, Liduan Zheng, Hong Liu
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A lesion categorized between ghost cell odontogenic carcinoma and dentinogenic ghost cell tumor with CTNNB1 mutation
Yae Ohata, Kou Kayamori, Akane Yukimori, Kanako Sumikura, Toshimitsu Ohsako, Hiroyuki Harada, Kei Sakamoto, Tohru Ikeda
Pathology International.2018; 68(5): 307. CrossRef
A case of large ghost cell odontogenic carcinoma arising in the mandible
Daisuke ARAKI, Shunichi YOSHIDA, Keisuke KOYAMA, Shuutarou ISHII, Toshihiro HASEGAWA, Sadao OOYAMA
Japanese Journal of Oral and Maxillofacial Surgery.2018; 64(12): 708. CrossRef
Three-dimensional volumetric analysis of ghost cell odontogenic carcinoma using 3-D reconstruction software: a case report
João Pedro Perez Gomes, Andre Luiz Ferreira Costa, Carlos Takahiro Chone, Albina Messias de Almeida Milani Altemani, João Maurício Carrasco Altemani, Carmen Silvia Passos Lima
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology.2017; 123(5): e170. CrossRef
Ghost cell odontogenic carcinoma transformed from dentinogenic ghost cell tumor of the maxilla after recurrences
Sase Miwako, Itoh Hiroto, Nakano Takahumi, Hayasaka Junichi, Noguchi Tadahide, Jinbu Yoshinori, Mori Yoshiyuki
Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology.2017; 29(5): 438. CrossRef
Ki-67 and p53 expression in ghost cell odontogenic carcinoma: a case report and literature review
G. Del Corso, M. L. Tardio, D. B. Gissi, C. Marchetti, L. Montebugnoli, A. Tarsitano
Oral and Maxillofacial Surgery.2015; 19(1): 85. CrossRef
Integrative genomic analysis of ghost cell odontogenic carcinoma
Pinaki Bose, Erin D. Pleasance, Martin Jones, Yaoqing Shen, Carolyn Ch’ng, Caralyn Reisle, Jacqueline E. Schein, Andrew J. Mungall, Richard Moore, Yussanne Ma, Brandon S. Sheffield, Thomas Thomson, Steven Rasmussen, Tony Ng, Stephen Yip, Christopher W. Le
Oral Oncology.2015; 51(9): e71. CrossRef
Pediatric Metastatic Odontogenic Ghost Cell Carcinoma: A Multimodal Treatment Approach
Safia K. Ahmed, Masayo Watanabe, Daphne E. deMello, Thomas B. Daniels
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Predictive Factors of Potential Malignant Transformation in Recurrent Calcifying Cystic Odontogenic Tumor: Review of the Literature
Sepideh Mokhtari, Zhaleh Mohsenifar, Maedeh Ghorbanpour
Case Reports in Pathology.2013; 2013: 1. CrossRef

Multifocal Renal Cell Carcinoma of Different Histological Subtypes in Autosomal Dominant Polycystic Kidney Disease: Ki Yong Na, Hyun-Soo Kim, Yong-Koo Park, Sung-Goo Chang, Youn Wha Kim; Korean J Pathol. 2012;46(4):382-386. Published online August 23, 2012; DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.4.382

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Abstract PDF

Renal cell carcinoma (RCC) in autosomal dominant polycystic kidney (ADPKD) is rare. To date, 54 cases of RCC in ADPKD have been reported. Among these, only 2 cases have different histologic types of RCC. Here we describe a 45-year-old man who received radical nephrectomy for multifocal RCC with synchronous papillary and clear cell histology in ADPKD and chronic renal failure under regular hemodialysis. The case reported herein is another example of the rare pathological finding of RCC arising in a patient with ADPKD.

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The MSCT and MRI findings of collecting duct carcinoma
Q. Zhu, J. Wu, Z. Wang, W. Zhu, W. Chen, S. Wang
Clinical Radiology.2013; 68(10): 1002. CrossRef
Thyroid-like follicular carcinoma of the kidney in a patient with nephrolithiasis and polycystic kidney disease: a case report
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Diagnostic Pathology.2013;[Epub] CrossRef

Original Article

Diagnostic Features of Fine Needle Aspiration Cytology of Pleomorphic Adenoma, Adenoid Cystic Carcinoma, and Mucoepidermoid Carcinoma of Salivary Gland.: Eun Sook Nam, Won Bo Jo, Jung Ho Han, Insun Kim; Korean J Cytopathol. 1990;1(1):60-67.

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Abstract PDF: The evaluate the diagnostic findings of salivary gland tumors, we reexamined aspiration cytology smears of 7 cases of pleomorphic adenoma, 3 cases of adenoid cystic carcinoma, and 3 cases of mucoepidermoid carcinoma, performed during April 1986 to March 1990, which were comfurmed by surgical excision and histologic diagnosis. The results obtained are summarized as follows : 1. All cases of pleomorphic adenoma showed branching cellular clusters of epithelial and myoepithelial cells. Acellular elements including myxomatous and chondroid components were observed. There were no cellular pleomorphism and nucleoli. Keratinizing squamous epithelial cells and keratin pearls were noted. 2. The smears of adenoid cystic carcinoma showed cell balls or cell cords containing a central hyaline core. Nuclear atypism and the nucleoli were frequently observed. There were no keratinizing squamous epithelial cells. 3. The smears of mucoepidermoid carcinoma showed mainly sheets or clusters of intermediate cells and some mucin-producing cells. Some nuclear pleomorphism was observed. Mucinous material and many inflammatory cells were present in the background.

Case Reports

Simultaneous Pancreatic Serous Microcystic Adenoma and Intraductal Papillary Mucinous Tumor of the Pancreas: A Case Report.: Hyoung Jong Kwak, Young Kon Kim, Baik Hwan Cho, Woo Sung Moon; Korean J Pathol. 2011;45:S29-S31.; DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.S1.S29

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Abstract PDF: Serous cystadenomas of the pancreas account for approximately a third of pancreatic cystic neoplasms. Their coexistence with a second tumor is extremely rare. We now report a case of a serous microcystic adenoma combined with an intraductal papillary mucinous tumor of the pancreas in a 69-year-old man. Abdominal computed tomography scans demonstrated an incidental cystic mass in the body with cystic dilatation of the duct in the head of the pancreas. Central pancreatectomy with pancreatico-jejunostomy, and cyst excision of the pancreatic head were performed. Histologic examination demonstrated a serous microcystic cystadenoma in the body coexisting with an intraductal papillary mucinous adenoma in the head of the pancreas. This case study highlights the importance of careful intra-operative and pathologic examination for synchronous pancreatic tumors.

Cystic Nephroma: A Case Report and Comparing Literature Review with Mixed Epithelial and Stromal Tumor of Kidney.: Hyun Jung Kim, Choong Hee Noh, Giyoung Kwon, Eunah Shin, Jung Yeon Kim, Kyeongmee Park; Korean J Pathol. 2011;45:S25-S28.; DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.S1.S25

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Abstract PDF: Cystic nephroma (CN) is a benign cystic neoplasm composed of mixed epithelial and stromal elements. Less than 200 cases have been reported. We had a patient, a 41-year-old woman, who had a huge typical CN. The patient was admitted for a right renal mass that was found incidentally. On laparaoscopic right nephrectomy, there was an encapsulated 7 cm multilocular cystic mass at the upper pole. Microscopically, the cystic wall was lined by a single layer of low cuboidal or hobnail epithelium without a solid area. The thin septa were composed of bland, ovarian type spindle cells. The main differential diagnoses were mixed epithelial and stromal tumor (MEST), low grade multilocular renal cell carcinoma, and tubulocystic carcinoma. The results of immunohistochemical staining were cytokeratin 7/19(+/+) and CD10(-) in lining epithelium, estrogen receptor/progesterone receptor(+/+) in stromal cells. After surgery, she was free of recurrence for 10 months. We report this rare case and compare it with other cystic renal tumors, especially MEST.

Bronchial Brushing Cytologic Finding of Primary Pulmonary Adenoid Cystic Carcinoma Misinterpretated as Small Cell Carcinoma: A Case Report with Literature Review.: Hyun Jung Kim, Sangbong Choi, Jieun Kwon, Jeong Yeon Kim, Kyeongmee Park; Korean J Pathol. 2011;45(4):441-444.; DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.4.441

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Abstract PDF

An adenoid cystic carcinoma is a very rare primary pulmonary neoplasm. Bronchial washing and brushing cytological findings of pulmonary adenoid cystic carcinoma have rarely been described. Here, we report the bronchial brushing cytological findings of an adenoid cystic carcinoma, finally diagnosed in a 71-year-old female patient. The low-power view showed moderate cellularity and cohesive clusters of small to medium-sized cells. The high-power view revealed distinct nuclear moldings, a coarse chromatin pattern, and inconspicuous nucleoli, which was favorable to a diagnosis of small cell carcinoma. However, apoptotic bodies, nuclear debris, and mitoses were not seen frequently. The bronchial biopsy showed solid, trabecular, and cribriform patterns in small cells. Periodic acid Schiff staining disclosed globular basement membrane-like materials, and the immunohistochemical staining revealed the presence of myoepithelial cell components, strongly suggestive of a salivary gland type tumor, compatible with an adenoid cystic carcinoma. In this report, we describe the exfoliative cytological features of a pulmonary adenoid cystic carcinoma with emphasis on some diagnostic pitfalls.

Citations

Citations to this article as recorded by

Bronchial cytology of pulmonary adenoid cystic carcinoma – A multi-institute series with emphasis on immunocytochemistry
Joanna K.M. Ng, Ka Pang Chan, Gary M. Tse, Joshua J.X. Li
Annals of Diagnostic Pathology.2023; 64: 152132. CrossRef
Comprehensive Cytomorphologic Analysis of Pulmonary Adenoid Cystic Carcinoma: Comparison to Small Cell Carcinoma and Non-pulmonary Adenoid Cystic Carcinoma
Seokhwi Kim, Jinah Chu, Hojoong Kim, Joungho Han
Journal of Pathology and Translational Medicine.2015; 49(6): 511. CrossRef

Coexistence of Intrapulmonary Bronchogenic Cyst and Congenital Cystic Adenomatoid Malformation: A Case Report.: Mee Hye Oh, Eun Ah Jung, Ji Hye Lee, Hyun Deuk Cho, Ki Hyun Seo, Seock Yeol Lee, Young Tong Kim; Korean J Pathol. 2011;45(1):92-95.; DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.1.92

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Abstract PDF

Congenital cystic lesions of the lung are uncommon and a conjunction of two or more lesions is very rare. We report here on a case of coexisting intrapulmonary bronchogenic cyst and congenital cystic adenomatoid malformation in a 13-year-old female with a cystic mass in the right upper lobe of the lung. Computed tomography showed a cystic lesion measuring 2.5 cm with an air fluid level and surrounding multicystic lesions in the right upper lobe. On gross examination, the cut surface showed a cystic mass containing inspissated mucinous material, and the cystic mass was surrounded by multiple small cysts. Microscopically, the larger cystic cavity was lined with pseudostratified ciliated columnar epithelium. The submucosal tissue contained mucinous glands and plates of cartilage. The surrounding smaller cysts or irregular spaces were lined with bronchiolar-type respiratory epithelium. We propose that this hybrid lung lesion may represent the missing link in a common embryologic pathway determined by the timing of mesenchymal and epithelial interactions.

Citations

Citations to this article as recorded by

Case 2: Coexisting Cystic Lesions of Lung in a Term Neonate: A Management Dilemma
Bichitrananda Raut, Aakriti Soni, Susanta Kumar Badatya, Satish Saluja, Manoj Modi, Arun Soni
NeoReviews.2018; 19(9): e542. CrossRef

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