- Mucocele of the rectal stump: mucinous cystic neoplasm with low-grade dysplasia simulating low-grade appendiceal mucinous neoplasm
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Hasan Basri Aydin, Maria Faraz, A. David Chismark, Haiyan Qiu, Hwajeong Lee
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J Pathol Transl Med. 2025;59(2):139-146. Published online February 26, 2025
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DOI: https://doi.org/10.4132/jptm.2024.12.27
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- Mucoceles, commonly observed in the appendix, are mucin-filled, dilated structures arising from a range of etiologies. Cases associated with dysplastic or neoplastic epithelium can rupture and disseminate within the abdominopelvic cavity. Similar lesions in other parts of the colon are exceedingly rare, with only 16 colonic mucoceles having been reported. The first case of a colonic mucinous neoplasm with dysplasia resembling a low-grade appendiceal mucinous neoplasm involving rectal stump was described in 2016. Here, we present the second such case arising in the rectal stump, identified in a 44-year-old male with extensive surgical history. Microscopic examination revealed low-grade dysplastic epithelium lining the cyst and mucin dissecting into the stroma, without evidence of rupture or extramural mucin. The patient was followed for 16 months without recurrence or peritoneal disease. The exact etiology and outcome of these rare lesions remain unknown, requiring close follow-up.
- Inflammation and tissue remodeling contribute to fibrogenesis in stricturing Crohn’s disease: image processing and analysis study
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Mustafa Erdem Arslan, Rupinder Brar, Lianna Goetz, Dipti Karamchandani, Michael W. Mikula, Kyle Hodge, Hua Li, Sangtae Ahn, Hwajeong Lee
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J Pathol Transl Med. 2022;56(5):239-248. Published online July 4, 2022
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DOI: https://doi.org/10.4132/jptm.2022.05.18
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 Supplementary Material
- Background
Inflammation and structural remodeling may contribute to fibrogenesis in Crohn’s disease (CD). We quantified the immunoexpression of calretinin, CD34, and calprotectin as a surrogate for mucosal innervation, telocytes (interstitial cells playing a role in networking), and inflammation, respectively, and correlated them with bowel alterations in stricturing CD.
Methods
Primary resection specimens for ileal CD (n = 44, 31 stricturing CD, 13 inflammatory CD) were identified. Left-sided ulcerative colitis and trauma cases were used as controls. Proximal and distal margin and middle (diseased) sections were stained for calretinin, CD34, and calprotectin. Microscopic images were captured from the mucosa (calretinin), submucosa (calprotectin), and myenteric plexus (CD34), and the immunostaining was quantified using image processing and analysis. Bowel thickness at the corresponding sections were measured and correlated with the amount of immunoexpression.
Results
A total of 2,037 images were analyzed. In stricturing CD, submucosal alteration/thickening at the stricture site correlated with calprotectin staining and inversely correlated with calretinin staining at the proximal margin. Muscularis propria alteration/thickening at the stricture site correlated with mucosal calretinin staining at the proximal margin. Submucosal alteration/thickening at the proximal margin correlated with calretinin and CD34 staining at the proximal margin and inversely correlated with CD34 staining at the stricture site. Calretinin immunostaining at the distal margin was significantly higher in stricturing CD than the controls.
Conclusions
Inflammation and tissue remodeling appear to contribute to fibrogenesis in stricturing CD. Increased mucosal calretinin immunostaining distal to the diseased segment could be helpful in diagnosing CD in the right clinical context.
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Citations
Citations to this article as recorded by  - Serum S100A8/A9 Correlates to Surgery‐Free Interval in Idiopathic Subglottic Stenosis
Laura M. Mafla, Raymond J. So, Ibrahim Abd‐Elazem, Samuel L. Collins, Yee Chan‐Li, Gabriela Lilly, Ioan A. Lina, Alexander H. Gelbard, Alexander T. Hillel, Kevin M. Motz
The Laryngoscope.2025; 135(5): 1724. CrossRef - Telocytes in inflammatory bowel diseases: contributions to pathology and therapeutic potentials
Ronaldo Paolo Panganiban, Christina McAninch, Marina Chulkina, Irina V. Pinchuk
Frontiers in Cell and Developmental Biology.2025;[Epub] CrossRef
- Metastatic Insulinoma Presenting as a Liver Cyst
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Hua Li, Tony El Jabbour, Ankesh Nigam, Hwajeong Lee
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J Pathol Transl Med. 2019;53(2):148-151. Published online January 16, 2019
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DOI: https://doi.org/10.4132/jptm.2019.01.15
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Correction in: J Pathol Transl Med 2019;53(6):415
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6,040
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Citations
Citations to this article as recorded by - Hyperechogenicity and histopathological features of focal liver lesions
Kumiko Okino, Satoshi Wakasugi, Shin Ichihara
Journal of Medical Ultrasonics.2025; 52(1): 55. CrossRef - Malignant Insulinoma Is Largely Derived From Nonfunctioning Pancreatic Neuroendocrine Tumors
Run Yu
Pancreas.2020; 49(6): 733. CrossRef
- Idiopathic Noncirrhotic Portal Hypertension: An Appraisal
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Hwajeong Lee, Aseeb Ur Rehman, M. Isabel Fiel
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J Pathol Transl Med. 2016;50(1):17-25. Published online November 11, 2015
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DOI: https://doi.org/10.4132/jptm.2015.09.23
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19,828
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- Idiopathic noncirrhotic portal hypertension is a poorly defined clinical condition of unknown etiology. Patients present with signs and symptoms of portal hypertension without evidence of cirrhosis. The disease course appears to be indolent and benign with an overall better outcome than cirrhosis, as long as the complications of portal hypertension are properly managed. This condition has been recognized in different parts of the world in diverse ethnic groups with variable risk factors, resulting in numerous terminologies and lack of standardized diagnostic criteria. Therefore, although the diagnosis of idiopathic noncirrhotic portal hypertension requires clinical exclusion of other conditions that can cause portal hypertension and histopathologic confirmation, this entity is under-recognized clinically as well as pathologically. Recent studies have demonstrated that variable histopathologic entities with different terms likely represent a histologic spectrum of a single entity of which obliterative portal venopathy might be an underlying pathogenesis. This perception calls for standardization of the nomenclature and formulation of widely accepted diagnostic criteria, which will facilitate easier recognition of this disorder and will highlight awareness of this entity.
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Citations
Citations to this article as recorded by - Nodular regenerative hyperplasia: The role of the CK7 immunohistochemistry pattern of expression in diagnosis
Brooke B Bartow, Deepti Dhall, Goo Lee, Manjula Garapati, Chirag R Patel, Sameer Al Diffalha
American Journal of Clinical Pathology.2025; 163(2): 196. CrossRef - The potential roles of gut microbiome in porto-sinusoidal vascular disease: an under-researched crossroad
Yangjie Li, Lingna Lyu, Huiguo Ding
Frontiers in Microbiology.2025;[Epub] CrossRef - A Case of Non-cirrhotic Portal Hypertension With Antiphospholipid Syndrome
Mili Shah, Razia Gill, Priya Hotwani, Hamsika Moparty, Naresh Kumar, Dhir Gala, Vikash Kumar
Cureus.2024;[Epub] CrossRef - Systemic Disease and Portal Hypertension
Talal Khurshid Bhatti, Paul Y. Kwo
Current Hepatology Reports.2024; 23(1): 162. CrossRef - Porto-sinusoidal Vascular Disease: Classification and Clinical Relevance
Madhumita Premkumar, Anil C. Anand
Journal of Clinical and Experimental Hepatology.2024; 14(5): 101396. CrossRef - Evaluation of the histologic and immunohistochemical (CD34, glutamine synthetase) findings in idiopathic non-cirrhotic portal hypertension (INCPH)
Melek Büyük, Neslihan Berker, Doğu Vurallı Bakkaloğlu, İbrahim Volkan Şenkal, Zerrin Önal, Mine Güllüoğlu
Hepatology International.2024; 18(3): 1011. CrossRef - Porto-sinusoidal Vascular Disease and Portal Hypertension
Sarah Noble, Marguerite Linz, Eduardo Correia, Akram Shalaby, Leonardo Kayat Bittencourt, Seth N. Sclair
Clinics in Liver Disease.2024; 28(3): 455. CrossRef - Histopathological features of idiopathic portal hypertension: A systematic review and meta-analysis
Adnan Malik, Sohira Malik, Ahsan Farooq, Muhammad Imran Malik, Sadia Javaid
Science Progress.2024;[Epub] CrossRef - Porto-Sinusoidal Vascular Disease: A Concise Updated Summary of Epidemiology, Pathophysiology, Imaging, Clinical Features, and Treatments
Su Jin Jin, Won-Mook Choi
Korean Journal of Radiology.2023; 24(1): 31. CrossRef - Aetiology and clinical outcomes of non-cirrhotic portal hypertension in Singapore
PikEu Jason Chang, KimJun Kevin Teh, Mithun Sharma
Singapore Medical Journal.2023;[Epub] CrossRef - A Unique Presentation of Familial Idiopathic Colonic Varices
John Gallagher, Bill Quach, Tomoki Sempokuya, Anita Sivaraman
ACG Case Reports Journal.2023; 10(11): e01185. CrossRef - Obliterative Portal Venopathy
Thomas D. Schiano, Maria Isabel Fiel
Current Hepatology Reports.2023; 22(4): 263. CrossRef - Case report: Oxaliplatin-induced idiopathic non-cirrhotic portal hypertension: a case report and literature review
Jiayuan Ye, Yilian Xie, Yaojiang Xu, Nan Chen, Yifei Tu
Frontiers in Medicine.2023;[Epub] CrossRef - Clinical Course of Porto-Sinusoidal Vascular Disease Is Distinct From Idiopathic Noncirrhotic Portal Hypertension
Katharina Wöran, Georg Semmler, Mathias Jachs, Benedikt Simbrunner, David Josef Maria Bauer, Teresa Binter, Katharina Pomej, Albert Friedrich Stättermayer, Philipp Schwabl, Theresa Bucsics, Rafael Paternostro, Katharina Lampichler, Matthias Pinter, Michae
Clinical Gastroenterology and Hepatology.2022; 20(2): e251. CrossRef - Porto-sinusoidal vascular disorder
Andrea De Gottardi, Christine Sempoux, Annalisa Berzigotti
Journal of Hepatology.2022; 77(4): 1124. CrossRef - Interventional Management of Portal Hypertension in Cancer Patients
Max Kabolowsky, Lyndsey Nguyen, Brett E. Fortune, Ernesto Santos, Sirish Kishore, Juan C. Camacho
Current Oncology Reports.2022; 24(11): 1461. CrossRef - Pathological and imaging features of idiopathic non-cirrhotic portal hypertension
Ming-Jie Tan, Hui Liu, Hui-Guo Ding
World Chinese Journal of Digestology.2022; 30(16): 729. CrossRef - Bioinformatics Analysis of Common Genetic and Molecular Traits and Association of Portal Hypertension with Pulmonary Hypertension
MingYu Chen, YouPeng Chen, Ikram Ud Din
Journal of Healthcare Engineering.2022; 2022: 1. CrossRef - Key histopathologic features in idiopathic noncirrhotic portal hypertension: an interobserver agreement study and proposal for diagnostic criteria
Jiancong Liang, Chanjuan Shi, William D. Dupont, Safia N. Salaria, Won Jae Huh, Hernan Correa, Joseph T. Roland, Roman E. Perri, Mary Kay Washington
Modern Pathology.2021; 34(3): 592. CrossRef - Histological analyses of trucut liver biopsies from patients with noncirrhotic portal fibrosis and extra-hepatic portal vein obstruction
ArchanaGeorge Vallonthaiel, Vandana Baloda, Lavleen Singh, Rajni Yadav, Ragini Kilambi, Sudha Battu, Vishnubhatla Sreenivas, Sujoy Pal, SubratK Acharya, Siddhartha DattaGupta, Shalimar, Prasenjit Das
Indian Journal of Pathology and Microbiology.2021; 64(5): 127. CrossRef - Nodular regenerative hyperplasia – An under-recognized vascular disorder of liver
Neha Bakshi, Natasha Gulati, Archana Rastogi, Abhijit Chougule, Chhagan Bihari, Ankur Jindal
Pathology - Research and Practice.2020; 216(4): 152833. CrossRef - Interobserver study on histologic features of idiopathic non-cirrhotic portal hypertension
Michel Kmeid, Chunlai Zuo, Stephen M. Lagana, Won-Tak Choi, Jingmei Lin, Zhaohai Yang, Xiuli Liu, Maria Westerhoff, M. Isabel Fiel, Kajsa Affolter, Eun-Young K. Choi, Hwajeong Lee
Diagnostic Pathology.2020;[Epub] CrossRef - Histology of portal vascular changes associated with idiopathic non‐cirrhotic portal hypertension: nomenclature and definition
Maria Guido, Venancio A F Alves, Charles Balabaud, Prithi S Bathal, Paulette Bioulac‐Sage, Romano Colombari, James M Crawford, Amar P Dhillon, Linda D Ferrell, Ryan M Gill, Prodromos Hytiroglou, Yasuni Nakanuma, Valerie Paradis, Alberto Quaglia, Pierre E
Histopathology.2019; 74(2): 219. CrossRef - Idiopathic noncirrhotic portal hypertension
M. Isabel Fiel, Thomas D. Schiano
Seminars in Diagnostic Pathology.2019; 36(6): 395. CrossRef - Pathology of idiopathic non-cirrhotic portal hypertension
Maria Guido, Samantha Sarcognato, Diana Sacchi, Guido Colloredo
Virchows Archiv.2018; 473(1): 23. CrossRef - Spectrum of histopathological changes in patients with non-cirrhotic portal fibrosis
Abhijit Chougule, Archana Rastogi, Rakhi Maiwall, Chhagan Bihari, Vikrant Sood, Shiv Kumar Sarin
Hepatology International.2018; 12(2): 158. CrossRef - Hepatocellular nodules in vascular liver diseases
Christine Sempoux, Charles Balabaud, Valérie Paradis, Paulette Bioulac-Sage
Virchows Archiv.2018; 473(1): 33. CrossRef - Systemic lupus erythematosus complicated by noncirrhotic portal hypertension: A case report and review of literature
Qi-Bin Yang, Yong-Long He, Chun-Mei Peng, Yu-Feng Qing, Qi He, Jing-Guo Zhou
World Journal of Clinical Cases.2018; 6(13): 688. CrossRef - Prevalence of histological features of idiopathic noncirrhotic portal hypertension in general population: a retrospective study of incidental liver biopsies
Chunlai Zuo, Vaibhav Chumbalkar, Peter F. Ells, Daniel J. Bonville, Hwajeong Lee
Hepatology International.2017; 11(5): 452. CrossRef - The pathological differential diagnosis of portal hypertension
Raouf E. Nakhleh
Clinical Liver Disease.2017; 10(3): 57. CrossRef - Hepatic vascular diseases
Naziheh Assarzadegan, Robert A. Anders, Kiyoko Oshima
Diagnostic Histopathology.2017; 23(12): 553. CrossRef
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