- Comparison of Squamous Cell Carcinoma of the Tongue between Young and Old Patients
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Gyuheon Choi, Joon Seon Song, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim, Jong-Lyel Roh, Bu-Kyu Lee, Kyung-Ja Cho
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J Pathol Transl Med. 2019;53(6):369-377. Published online October 11, 2019
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DOI: https://doi.org/10.4132/jptm.2019.09.16
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 Abstract
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- Background
The worldwide incidence of squamous cell carcinoma of the tongue (SCCOT) in young patients has been increasing. We investigated clinicopathologic features of this unique population and compared them with those of SCCOT in the elderly to delineate its pathogenesis.
Methods
We compared clinicopathological parameters between patients under and over 45 years old. Immunohistochemical assays of estrogen receptor, progesterone receptor, androgen receptor, p53, p16, mdm2, cyclin D1, and glutathione S-transferase P1 were also compared between them.
Results
Among 189 cases, 51 patients (27.0%) were under 45 years of age. A higher proportion of women was seen in the young group, but was not statistically significant. Smoking and drinking behaviors between age groups were similar. Histopathological and immunohistochemical analysis showed no significant difference by age and sex other than higher histologic grades observed in young patients.
Conclusions
SCCOT in young adults has similar clinicopathological features to that in the elderly, suggesting that both progress via similar pathogenetic pathways.
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Citations
Citations to this article as recorded by  - High Failure Rates in Young Nonsmoker Nondrinkers With Squamous Cell Carcinoma of the Oral Tongue
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The Laryngoscope.2023; 133(5): 1110. CrossRef - Characteristics of oral squamous cell carcinoma focusing on cases unaffected by smoking and drinking: A multicenter retrospective study
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Head & Neck.2023; 45(7): 1812. CrossRef - Genetic characteristics of advanced oral tongue squamous cell carcinoma in young patients
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Oral Oncology.2023; 144: 106466. CrossRef - Oral Squamous Cell Carcinoma Frequency in Young Patients from Referral Centers Around the World
Rafael Ferreira e Costa, Marina Luiza Baião Leão, Maria Sissa Pereira Sant’Ana, Ricardo Alves Mesquita, Ricardo Santiago Gomez, Alan Roger Santos-Silva, Syed Ali Khurram, Artysha Tailor, Ciska-Mari Schouwstra, Liam Robinson, Willie F. P. van Heerden, Rami
Head and Neck Pathology.2022; 16(3): 755. CrossRef - Early-onset oral cancer as a clinical entity: aetiology and pathogenesis
E.S. Kolegova, M.R. Patysheva, I.V. Larionova, I.K. Fedorova, D.E. Kulbakin, E.L. Choinzonov, E.V. Denisov
International Journal of Oral and Maxillofacial Surgery.2022; 51(12): 1497. CrossRef - The effect of age on the clinicopathological features of oral squamous cell carcinoma
Alaa S Saeed, Bashar H Abdullah
Journal of Baghdad College of Dentistry.2022; 34(1): 25. CrossRef - Survival Outcomes in Oral Tongue Cancer: A Mono-Institutional Experience Focusing on Age
Mohssen Ansarin, Rita De Berardinis, Federica Corso, Gioacchino Giugliano, Roberto Bruschini, Luigi De Benedetto, Stefano Zorzi, Fausto Maffini, Fabio Sovardi, Carolina Pigni, Donatella Scaglione, Daniela Alterio, Maria Cossu Rocca, Susanna Chiocca, Sara
Frontiers in Oncology.2021;[Epub] CrossRef - A Meta-analysis of Oral Squamous Cell Carcinoma in Young Adults with a Comparison to the Older Group Patients (2014–2019)
Khadijah Mohideen, C. Krithika, Nadeem Jeddy, Thayumanavan Balakrishnan, R. Bharathi, S. Leena Sankari
Contemporary Clinical Dentistry.2021; 12(3): 213. CrossRef - Modern perspectives of oral squamous cell carcinoma
A.A. Ivina
Arkhiv patologii.2020; 82(3): 55. CrossRef
- Primary Merkel cell carcinoma of the salivary gland: a clinicopathologic study of four cases with a review of literature
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Gyuheon Choi, Joon Seon Song, Hee Jin Lee, Gi Hwan Kim, Young Ho Jung, Yoon Se Lee, Kyung-Ja Cho
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Received November 18, 2024 Accepted March 25, 2025 Published online April 30, 2025
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DOI: https://doi.org/10.4132/jptm.2025.03.25
[Epub ahead of print]
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Abstract
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- Background
Primary Merkel cell carcinoma of the salivary gland is currently not listed in the World Health Organization classification. However, cases of Merkel cell type neuroendocrine carcinomas of the salivary gland with perinuclear cytokeratin 20 positivity have been intermittently reported. We here investigated the clinicopathologic features of additional cases.
Methods
Data of four cases of Merkel cell type small cell neuroendocrine carcinoma of the salivary gland were retrieved. To confirm the tumors’ primary nature, clinical records and pathologic materials were reviewed. Optimal immunohistochemical staining was performed to support the diagnosis.
Results
All tumors were located in the parotid gland. Possibilities of metastasis were excluded in all cases through a meticulous clinicopathological review. Tumor histology was consistent with the diagnosis of small cell neuroendocrine carcinoma. Tumors’ immunohistochemical phenotypes were consistent with Merkel cell carcinoma, including Merkel cell polyomavirus large T antigen positivity in two of the four cases.
Conclusions
Merkel cell carcinomas can originate in salivary glands and are partly associated with Merkel cell polyomavirus infection as in cutaneous Merkel cell carcinomas.
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