- EGFR-mutated pulmonary adenocarcinoma with concurrent PIK3CA mutation, and with acquired RET fusion and EGFR T790M mutation after afatinib therapy
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Minhye Kim, Ji Min Na, Gyeong-Won Lee, Seung Jun Lee, Jong Duk Kim, Jung Wook Yang
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J Pathol Transl Med. 2021;55(1):79-82. Published online December 3, 2020
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DOI: https://doi.org/10.4132/jptm.2020.11.02
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Citations
Citations to this article as recorded by  - Case report: First evidence of impressive efficacy of modulated dose selpercatinib in a young Caucasian with ANK3-RET fusion-positive NSCLC
Elisa De Carlo, Elisa Bertoli, Monica Schiappacassi, Brigida Stanzione, Alessandro Del Conte, Roberto Doliana, Michele Spina, Alessandra Bearz
Frontiers in Oncology.2024;[Epub] CrossRef - RET Proto-Oncogene—Not Such an Obvious Starting Point in Cancer Therapy
Tomasz Kucharczyk, Paweł Krawczyk, Dariusz M. Kowalski, Adam Płużański, Tomasz Kubiatowski, Ewa Kalinka
Cancers.2022; 14(21): 5298. CrossRef
- Prognostic Role of S100A8 and S100A9 Protein Expressions in Non-small Cell Carcinoma of the Lung
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Hyun Min Koh, Hyo Jung An, Gyung Hyuck Ko, Jeong Hee Lee, Jong Sil Lee, Dong Chul Kim, Jung Wook Yang, Min Hye Kim, Sung Hwan Kim, Kyung Nyeo Jeon, Gyeong-Won Lee, Se Min Jang, Dae Hyun Song
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J Pathol Transl Med. 2019;53(1):13-22. Published online November 26, 2018
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DOI: https://doi.org/10.4132/jptm.2018.11.12
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 Abstract
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- Background
S100A8 and S100A9 have been gaining recognition for modulating tumor growthand metastasis. This study aimed at evaluating the clinical significance of S100A8 and S100A9 innon-small cell lung cancer (NSCLC).
Methods
We analyzed the relationship between S100A8and S100A9 expressions, clinicopathological characteristics, and prognostic significance in tumorcells and peritumoral inflammatory cells.
Results
The positive staining of S100A8 in tumorcells was significantly increased in male (p < .001), smoker (p = .034), surgical method other thanlobectomy (p = .024), squamous cell carcinoma (SQCC) (p < .001) and higher TNM stage (p = .022)compared with female, non-smoker, lobectomy, adenocarcinoma (ADC), and lower stage. Theproportion of tumor cells stained for S100A8 was related to histologic type (p < .001) and patientsex (p = .027). The proportion of inflammatory cells stained for S100A8 was correlated with patientage (p = .022), whereas the proportion of inflammatory cells stained for S100A9 was correlatedwith patient sex (p < .001) and smoking history (p = .031). Moreover, positive staining in tumorcells, more than 50% of the tumor cells stained and less than 30% of the inflammatory cellsstained for S100A8 and S100A9 suggested a tendency towards increased survivability in SQCCbut towards decreased survivability in ADC.
Conclusions
S100A8 and S100A9 expressions might be potential prognostic markers in patients with NSCLC.
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Citations
Citations to this article as recorded by - S100A8 as a potential therapeutic target for cancer metastasis
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Bagher Khalvati, Kaveh Kavousi, Amir Hosein Keyhanipour, Masoud Arabfard
Discover Oncology.2025;[Epub] CrossRef - The role of S100A8 and S100A9 in external auditory canal cholesteatoma
Guanwen He, Weijing Han, Zhongshou Zhu, Rifu Wei, Chang Lin
Frontiers in Immunology.2024;[Epub] CrossRef - Gene expression related to lung cancer altered by PHMG-p treatment in PBTE cells
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Molecular & Cellular Toxicology.2023; 19(1): 205. CrossRef - Discovery of protein biomarkers for venous thromboembolism in non-small cell lung cancer patients through data-independent acquisition mass spectrometry
Yanhong Liu, Lan Gao, Yanru Fan, Rufei Ma, Yunxia An, Guanghui Chen, Yan Xie
Frontiers in Oncology.2023;[Epub] CrossRef - S100A8 and S100A9 in Cancer
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Biochimica et Biophysica Acta (BBA) - Reviews on Cancer.2023; 1878(3): 188891. CrossRef - Gene expression of S100a8/a9 predicts Staphylococcus aureus-induced septic arthritis in mice
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Frontiers in Oncology.2022;[Epub] CrossRef - The S100 protein family in lung cancer
Ting Wang, Ge Du, Dong Wang
Clinica Chimica Acta.2021; 520: 67. CrossRef - The associations of serum S100A9 with the severity and prognosis in patients with community-acquired pneumonia: a prospective cohort study
Hong-Yan Liu, Hui-Xian Xiang, Ying Xiang, Zheng Xu, Chun-Mei Feng, Jun Fei, Lin Fu, Hui Zhao
BMC Infectious Diseases.2021;[Epub] CrossRef - Saliva proteomic analysis reveals possible biomarkers of renal cell carcinoma
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Open Chemistry.2020; 18(1): 918. CrossRef - Prognostic Role of S100A8 in Human Solid Cancers: A Systematic Review and Validation
An Huang, Wei Fan, Jiacui Liu, Ben Huang, Qingyuan Cheng, Ping Wang, Yiping Duan, Tiantian Ma, Liangyue Chen, Yanping Wang, Mingxia Yu
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