- Tumor-to-tumor metastasis: metastatic invasive lobular carcinoma of the breast within adenocarcinoma of the lung
-
Myoung Jae Kang, Ae Ri An, Myoung Ja Chung, Kyoung Min Kim
-
J Pathol Transl Med. 2020;54(2):188-191. Published online September 16, 2019
-
DOI: https://doi.org/10.4132/jptm.2019.09.07
-
-
5,188
View
-
159
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-
6
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-
6
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-
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-
Citations
Citations to this article as recorded by  - Unraveling Tumor-to-Tumor Metastasis: Insights into Pathogenesis, Diagnostic Challenges, and Treatment Modalities
Wennei Mei, Dongdong Zhang
Biologics: Targets and Therapy.2025; Volume 19: 43. CrossRef - Tumor-in-Tumor-Metastase: Ein seltenes Phänomen
Felix Elsner, Katharina Keller, Florian Fuchs, Michael Uder, Arndt Hartmann
Die Pathologie.2024;[Epub] CrossRef - Tumor-to-Tumor Metastases Involving Clear Cell Renal Cell Carcinomas: A Diagnostic Challenge for Pathologists Needing Clinical Correlation
Claudia Manini, Claudia Provenza, Leire Andrés, Igone Imaz, Rosa Guarch, Raffaelle Nunziata, José I. López
Clinics and Practice.2023; 13(1): 288. CrossRef - Metástasis tumor a tumor en pulmón: reporte de tres casos y revisión de la literatura
Paula Cristina Castro Quiroga, Blanca Viviana Fajardo Idrobo, Diana Marcela Caicedo Ruiz, Julieth Alexandra Franco Mira, Carlos Andrés Carvajal Fierro, Alfredo Ernesto Romero Rojas, Rafael Santiago Parra Medina
Revista Colombiana de Cancerología.2023; 27(1): 107. CrossRef - Lobular to Lobule: Metastatic Breast Carcinoma to Olfactory Neuroblastoma
Kent M. Swimley, Silvana Di Palma, Lester D. R. Thompson
Head and Neck Pathology.2021; 15(2): 642. CrossRef - A case of colorectal cancer with intratumoral metastasis to primary lung cancer
Yasushi Cho, Mitsuhito Kaji, Shunsuke Nomura, Yusuke Motohashi, Masaaki Sato, Motoya Takeuchi
The Journal of the Japanese Association for Chest Surgery.2021; 35(5): 576. CrossRef
- Pseudomesotheliomatous carcinoma of the lung in the parietal pleura
-
Ae Ri An, Kyoung Min Kim, Jong Hun Kim, Gong Yong Jin, Young Hoon Choe, Myoung Ja Chung
-
J Pathol Transl Med. 2020;54(2):192-195. Published online January 29, 2020
-
DOI: https://doi.org/10.4132/jptm.2019.11.14
-
-
5,776
View
-
143
Download
-
2
Web of Science
-
3
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-
PDF
-
Citations
Citations to this article as recorded by - Pseudomesotheliomatous Carcinoma of the Lung with Morphological Characteristics of Signet Ring Cell Carcinoma: An Autopsy Case Report
Tetsu Hirakawa, Takuya Tanimoto, Yui Hattori, Ryo Katsura, Shinya Miyake, Suguru Fujita, Sayaka Ueno, Ken Masuda, Takashi Nishisaka, Nobuhisa Ishikawa
Internal Medicine.2024; 63(7): 979. CrossRef - Intrapulmonary Biphasic Mesothelioma Misdiagnosed as Adenocarcinoma: Case Report and a Potential Diagnostic Pitfall
Wenfeng Xu, XingYan Zhu, Hao Tang, Qijian Ying, Yujuan Xu, Deyu Guo
OncoTargets and Therapy.2024; Volume 17: 925. CrossRef -
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B.M. Fylenko, N.V. Royko, I.I. Starchenko, O.V. Starchenko, O.Y. Horodynska, S.A. Proskurnia
Azerbaijan Medical Journal.2024; (4): 182. CrossRef
- Association between Expression of 8-OHdG and Cigarette Smoking in Non-small Cell Lung Cancer
-
Ae Ri An, Kyoung Min Kim, Ho Sung Park, Kyu Yun Jang, Woo Sung Moon, Myoung Jae Kang, Yong Chul Lee, Jong Hun Kim, Han Jung Chae, Myoung Ja Chung
-
J Pathol Transl Med. 2019;53(4):217-224. Published online March 11, 2019
-
DOI: https://doi.org/10.4132/jptm.2019.02.20
-
-
7,611
View
-
240
Download
-
19
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-
19
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-
 Abstract
PDF
- Background
Exposure to cigarette smoking (CS) is a major risk factor for the development of lung cancer. CS is known to cause oxidative DNA damage and mutation of tumor-related genes, and these factors are involved in carcinogenesis. 8-Hydroxydeoxyguanosine (8-OHdG) is considered to be a reliable biomarker for oxidative DNA damage. Increased levels of 8-OHdG are associated with a number of pathological conditions, including cancer. There are no reports on the expression of 8-OHdG by immunohistochemistry in non-small cell lung cancer (NSCLC).
Methods
We investigated the expression of 8-OHdG and p53 in 203 NSCLC tissues using immunohistochemistry and correlated it with clinicopathological features including smoking.
Results
The expression of 8-OHdG was observed in 83.3% of NSCLC. It was significantly correlated with a low T category, negative lymph node status, never-smoker, and longer overall survival (p < .05) by univariate analysis. But multivariate analysis revealed that 8-OHdG was not an independent prognostic factor for overall survival in NSCLC patients. The aberrant expression of p53 significantly correlated with smoking, male, squamous cell carcinoma, and Ki-67 positivity (p < .05).
Conclusions
The expression of 8-OHdG was associated with good prognostic factors. It was positively correlated with never-smokers in NSCLC, suggesting that oxidative damage of DNA cannot be explained by smoking alone and may depend on complex control mechanisms.
-
Citations
Citations to this article as recorded by - Sustainable framework for automated segmentation and prediction of lung cancer in CT image using CapsNet with U-net segmentation
S.R. Vijayakumar, S. Aarthy, D. Deepa, P. Suresh
Biomedical Signal Processing and Control.2025; 99: 106873. CrossRef - Increased pretreatment triglyceride glucose-body mass index associated with poor prognosis in patients with advanced non-small cell lung cancer
Shaoming Guo, Yi Zhao, Yue Jiang, Huaping Ye, Ying Wang
Clinical Nutrition ESPEN.2024; 59: 412. CrossRef - Oxidative Damage and Telomere Length as Markers of Lung Cancer Development among Chronic Obstructive Pulmonary Disease (COPD) Smokers
Elizabeth Córdoba-Lanús, Luis M. Montuenga, Angélica Domínguez-de-Barros, Alexis Oliva, Delia Mayato, Ana Remírez-Sanz, Francisca Gonzalvo, Bartolomé Celli, Javier J. Zulueta, Ciro Casanova
Antioxidants.2024; 13(2): 156. CrossRef - Automated determination of 8-OHdG in cells and tissue via immunofluorescence using a specially created antibody
Tobias Jung, Nicole Findik, Bianca Hartmann, Katja Hanack, Kai Grossmann, Dirk Roggenbuck, Marc Wegmann, René Mantke, Markus Deckert, Tilman Grune
Biotechnology Reports.2024; 42: e00833. CrossRef - Combination treatment of zinc and selenium intervention ameliorated BPA-exposed germ cell damage in SD rats: elucidation of molecular mechanisms
Chittaranjan Sahu, Gopabandhu Jena
Naunyn-Schmiedeberg's Archives of Pharmacology.2024; 397(9): 6685. CrossRef - Interplay of arsenic exposure and cigarette smoking on oxidative DNA damage in healthy males
Sepideh Nemati-Mansour, Mohammad Mosaferi, Javad Babaie, Asghar Mohammadpoorasl, Reza Dehghanzadeh, Leila Nikniaz, Mohammad Miri
Environmental Sciences Europe.2024;[Epub] CrossRef - The role of tissue persistent organic pollutants and genetic polymorphisms in patients with benign and malignant kidney tumors
Rasih Kocagöz, İlgen Onat, Merve Demirbügen Öz, Burak Turna, Banu Sarsık Kumbaracı, Mehmet Nurullah Orman, Halit Sinan Süzen, Hilmi Orhan
Environmental Toxicology and Pharmacology.2024; 110: 104495. CrossRef - Mitochondrial Plasticity and Glucose Metabolic Alterations in Human Cancer under Oxidative Stress—From Viewpoints of Chronic Inflammation and Neutrophil Extracellular Traps (NETs)
Hui-Ting Lee, Chen-Sung Lin, Chao-Yu Liu, Po Chen, Chang-Youh Tsai, Yau-Huei Wei
International Journal of Molecular Sciences.2024; 25(17): 9458. CrossRef - Oxidative DNA Damage and Arterial Hypertension in Light of Current ESC Guidelines
Radka Hazuková, Zdeněk Zadák, Miloslav Pleskot, Petr Zdráhal, Martin Pumprla, Miloš Táborský
International Journal of Molecular Sciences.2024; 25(23): 12557. CrossRef - Significance of 8-OHdG Expression as a Predictor of Survival in Colorectal Cancer
Myunghee Kang, Soyeon Jeong, Sungjin Park, Seungyoon Nam, Jun-Won Chung, Kyoung Oh Kim, Jungsuk An, Jung Ho Kim
Cancers.2023; 15(18): 4613. CrossRef - Serum 8-Hydroxy-2′-deoxyguanosine Predicts Severity and Prognosis of Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Peng Cao, Chen Zhang, Dong-Xu Hua, Meng-Die Li, Bian-Bian Lv, Lin Fu, Hui Zhao
Lung.2022; 200(1): 31. CrossRef - Redox signaling at the crossroads of human health and disease
Jing Zuo, Zhe Zhang, Maochao Luo, Li Zhou, Edouard C. Nice, Wei Zhang, Chuang Wang, Canhua Huang
MedComm.2022;[Epub] CrossRef - Assessment of MDA and 8-OHdG expressions in ovine pulmonary adenocarcinomas by immunohistochemical and immunofluorescence methods
Emin Karakurt, Enver Beytut, Serpil Dağ, Hilmi Nuhoğlu, Ayfer Yıldız, Emre Kurtbaş
Acta Veterinaria Brno.2022; 91(3): 235. CrossRef - Dietary Antioxidants and Lung Cancer Risk in Smokers and Non-Smokers
Naser A. Alsharairi
Healthcare.2022; 10(12): 2501. CrossRef - Targeting oxidative stress in disease: promise and limitations of antioxidant therapy
Henry Jay Forman, Hongqiao Zhang
Nature Reviews Drug Discovery.2021; 20(9): 689. CrossRef - Association between tobacco substance usage and a missense mutation in the tumor suppressor gene P53 in the Saudi Arabian population
Mikhlid H. Almutairi, Bader O. Almutairi, Turki M. Alrubie, Sultan N. Alharbi, Narasimha R. Parine, Abdulwahed F. Alrefaei, Ibrahim Aldeailej, Abdullah Alamri, Abdelhabib Semlali, Alvaro Galli
PLOS ONE.2021; 16(1): e0245133. CrossRef - Measurement of uranium concentrations in urine samples of adult healthy groups in Najaf governorate with estimation of urine concentrations of 8-OHdG compound as biomarker for DNA damage
Samia K. Abbas, Dhuha S. Saleh, Hayder S. Hussain
Journal of Physics: Conference Series.2021; 1879(3): 032097. CrossRef - Common Data Model and Database System Development for the Korea Biobank Network
Soo-Jeong Ko, Wona Choi, Ki-Hoon Kim, Seo-Joon Lee, Haesook Min, Seol-Whan Oh, In Young Choi
Applied Sciences.2021; 11(24): 11825. CrossRef - EVALUATION OF OXIDATIVE STATUS IN PATIENTS WITH CHRONIC PERIODONTITIS AND ADDITIONAL TOBACCO ABUSE: A CROSS-SECTIONAL STUDY
Didem ÖZKAL EMİNOĞLU, Varol ÇANAKÇI
Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi.2020; : 1. CrossRef
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