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The Korean Journal of Pathology 1992;26(4): 348-354.
Hydatidiform Mole with a Coexisting Fetus: Report of three cases with nuclear DNA ploidy analysis by flow cytometry or chromosomal analysis.
Kyu Rae Kim, Dong Hee Choi, Woo Hee Jung, Yong Hyun Park, Myong Ock Ahn, Seon Hee Cha
1Department of Pathology, Cha Women's Hospital, Seoul, Korea.
2Department of Obstetric and Gynecology, Cha Women's Hospital, Seoul, Korea.
3Department of Radiology, Cha Women's Hospital, Seoul, Korea.
4Department of Pathology, Yonsei University College of Medicine, Seoul, Korea.
Three cases of hydatidiform mole with a coexisting fetus are described. In two cases, flow cytometric analysis of nuclear DNA content from paraffin-embedded, molar tissues and normal-appearing placental tissues showed diploid pattern. One case had karyotypes of 46, XX both in fetal skin fibroblasts and in molar tissues. Microscopically, the villi showed diffuse hydropic swelling with circumferential trophoblastic proliferations and consistent with the diagnosis of complete mole. Two patient had persistent gestational trophoblastic neoplasia on the follow-up. Therefore, in cases of hydatidiform mole with a coexisting fetus, dizygotic twin pregnancies composed of a normal pregnancy from one ovum and a complete mole pregnancy from the other ovum must be considered and the patients should be followed with serum beta-hCG measurements.
Key Words: Hydatidiform mole; Coexisting fetus; Diploidy; Twin
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