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The Korean Journal of Pathology 1992;26(1): 62-65.
Epidermolysis Bullosa Simplex Generalisata.
Kye Yong Song, Joong Seok Seo, Sung Hye Park, Je G Chi, Kwang Hyun Cho
1Department of Pathology, College of Medicine, Seoul National University, Seoul, Korea.
2Department of Pathology, College of Medicine, Chung-Ang University, Seoul, Korea.
3Department of Dermatology, College of Medicine, Seoul National University, Seoul, Korea.
We report a case of epidermolysis bullosa simplex occurred in a 12-year-old girl, who presented with intractable bullous lesions of the hands and feet after minor traumas ever since her early neonatal period. The bullous lesions were noted on the 2nd and 4th webs of the fingers and dorsum of the hands as well as on the skin of the ankle. The lesions were healed without scar formation. Family history was not contributary and seasonal pattern was not noted. Histologic sections revealed intraepidermal bullae just above the well preserved basement membrane. Electron microscopic findings revealed cytolysis of basal cells with preservation of the basement membrane, indicating the epidermal type of epidermolysis bullosa simplex.
Key Words: Epidermolysis bullosa simplex; Mechanobullous disease; Skin
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