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The Korean Journal of Pathology 1991;25(6): 570-575.
Placental Site Trophoblastic Tumor(PSTT) with Vaginal Metastasis: A case report.
Yee Jeong Kim, Kyu Rae Kim, Soon Hee Jeong, Ho Geun Kim, Jang Yeon Kwon
1Department of Pathology, Yonsei University, Seoul, Korea.
2Department of Obstetrics and Gynecology, Yonsei University, Seoul, Korea.
3Department of Pathology, Cha Women's Hospital, Seoul, Korea.
PSTT has been established as a separate entity distinct from choriocarcinoma since 1983, because of its different morphological features, biologic behavior and response to chemotherapy. Most cases of PSTT have indolent clinical courses, but there have been several reports showing malignant behavior resulted in death of the patient. We report a case of PSTT showing vaginal metastatis. In biopsy specimen, it was difficult to make differential diagnosis from squamous cell carcinoma of uterine cervix due to uniform and mononuclear cytologic characteristics. Immunohistochemical stains for hPL and hCG were not typical for either PSTT or choriocarcinoma. We suggest that poorly differentiated PSTT may synthesize the lesser amount of hPL than typical PSTT and it may behave more aggressively.
Key Words: Placental site trophoblastic tumor; hPL; hCG; Choriocarcinoma