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The Korean Journal of Pathology 1991;25(5): 407-417.
Immunopathologic Study and Clinical Correlation of Non-Hodgkin's Lymphoma.
Mi Seon Lee, Jin Man Kim, Kwang Sun Suh, Dae Young Kang
1Department of Pathology, Daejeon Sun General Hospital, Daejeon 301-070, Korea.
2Department of Pathology, College of Medicine, Chungnam National University, Korea.
ABSTRACT
In Korea, the proportion of B-cell and T-cell lymphomas has not yet been clearly estimated. In the present study, we analysed clinicopathologic and immunophenotypic findings in 60 cases of non-Hodgkin's lymphomas(NHL) and in 17 cases of polymorphic reticulosis. Immunohistochemical studies for monoclonal antibodies, such as MB2, UCHL-1, Kappa/Lambda light chains, and IgG/IgM/IgD heavy chains were performed on formaldehyde-fixed paraffin embedded tissue sections. Among 60 cases of NHL, 28 cases(46.7%) expressed B-cell markers, 29 cases(48.3%) T-cell markers, and 3 cases(5.0%) lacked detectable markers, whereas 16 of 17 cases(94.2%) of polymorphic reticulosis reacted with T-cell markers. The mean survival of the 16 cases of T-cell lymphoma group was shorter than that of the lymphoma group positive for B-cell markers.
Key Words: Monoclonal antibodies; B-cell lymphoma; T-cell lymphoma; Polymorphic reticulosis