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The Korean Journal of Pathology 1990;24(2): 95-102.
Detection of Human Papillomavirus 16/18, 31/33/35 in Verrucous Carcinoma of the Larynx by In Situ Hybridization with Human Papillomavirus DNA Probes.
Ki Kwon Kim, Sang Sook Lee, June Sik Park, Seung Won Jin, U Ik Sohn
1Department of Pathology, Keimyung University School of Medicine, Taegu, Korea.
2Department of Otolaryngology, Kyungpook National University School of Medicine, Taegu, Korea.
ABSTRACT
Verrucous carcinoma of the larynx is a distinct and uncommon variant of well-differentiated squamous cell-carcinoma. The authors hybridized in situ a case of laryngeal verrucous carcinoma with DNA prebes to humman papillomavirus (HPV) 6, 11, 16, 18, 31, 33 and 35. The DNAs from the verrucous carcinoma of larynx hybridized with mixed DNA probes HPV-16/18 and 31/33/35. In addition, there was an evidence of HPV infection based on hybridization with mixed DNA probe HPV-6/11 in the adjacent papilloma tissue. By in situ DNA hybridization techniques, we clearly demonstrated human papillomavirus (HPV-16/18, and 31/33/35) related sequences in this neoplasm. These findings suggest the role of HPV-6/11 in the development of laryngeal papilloma ad HPV-16/18 and 31/33/35 probably on the progression to verrucous carcinoma.
Key Words: Humman papilloma virus; Verrucous carcinoma; Larynx; In situ hybridization