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The Korean Journal of Pathology 1989;23(1): 75-84.
Immunohistochemical Demonstration of Neuron-Specific Enolase and Chromogranin and Ultrastructural Studies on Endocrine Carcinoma of the Uterine Cervix.
H J Chun, K H Kee, S C Lim, Hae Sook Song, M W Kim, S J Han, C H Suh
1Department of Pathology, Medical College, Chosun University, Kwangju, Korea.
2Department of Internal Medicine, Medical College, Chosun University, Kwangju, Korea.
3Department of Obstetrics and Gynecology, Medical College, Chosun University, Kwangju, Korea.
ABSTRACT
Three cases of endocrine carcinoma, well differentiated type of the uterine cervix, were found in a study of 201 cases listed in the files of the Chosun University medical college as malignant tumors in the uterine cervix based on light microscopic pattern, three cases were divided into pure endocrine carcinoma (2 cases) and endocrine carcinoma mixed with large cell nonkeratinizing squamous cell carcinoma (1 case). The histologic picture of these lesions varied from solid sheets to glandular patterns and show monotonous and intermediate size of neclei. Argyrophilic granules were demonstrated in two pure forms by Grimelius stain, and Masson-Hamperl (argentaffin) stain were negative in all three cases. Immunohistochemical studies demonstrated positive reactions for neuron specific enolase and chromogranin in all three cases. Although endocrine symptoms were not found, ACTH were demonstrated in two pure forms. Ultrastructural studies disclose distinct membrane bounded neurosecretory granules and well defined Golgi complex.
Key Words: Endocrine carcinoma; Uterine cervix