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The Korean Journal of Pathology 1989;23(1): 29-35.
A Study on the Cell Kinetics of the Dysplastic Epithelium in the Stomach.
Jong Hee Nahm, Kyu Hyuk Cho
Department of Pathology, Chonnam University Medical School, Kwangju, Korea.
This study was designed to evaluate the biological behavior of the dysplastic lesion of the stomach by applying immunohistochemical method for bromodeoxyuridine (BrdUrd). The results obtained were as follows. 1) In most hyperplastic and dysplastic lesions, the proliferative cell zones, loci of BrdUrd-labelled cells, were found in the upper later of the mucosa, whereas they were confined to the neck zone in the normal gastric mucosa. 2) The labelling indices (LIs), percentages of BrdUrd-labelled cells, were 11.0% to 13.6% in the normal gastric mucosa, and were 14.3% to 17.9%, 16.4% to 19.2% and 17.4% to 20.7% in the simple hyperplasia, in the atypical hyperplasia and in the dysplasia, respectively. These findings suggested that proliferative potential in hyperplasia and dysplasia were greater than that in normal gastric mucosa, the higher the grade of dysplasia being, the greater the proliferative potentials.
Key Words: Gastric dysplasia; Cell kinetics; Bromodeoxyuridine; Immunohistochemistry; Monoclonal antibody