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The Korean Journal of Pathology 1988;22(3): 308-316.
Congenital Acute Myelocytic Leukemia: An autopsy case.
Kyu Rae Kim, Eun Kyoung Han, In Joon Choi, Chang Hyun Yang, Kir Young Kim
Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea.
ABSTRACT
Leukemia is a rare disease in the newborn infant. We have presented an autopsy case of congenital acute myelocytic leukemia in a female neonate and discussecd with review of literature. At birth, she was relatively in good health with 4.2 kg in body weight except a large cephalhematoma on left parietal scalp and multiple subcutaneous nodules with ecchymosis on entire body surface. Hemoglobin concentration was 12.0 gm/, Hct 34.6% and erythrocyte count was 2.24 millions. Of 212,400 leukocytes/mm2, 47% were myeloblast. Biopsy of skin nodules reveal leukemia cutis, which disappear dramatically with anticancer drug. The infant was expired 12 days after admission due to intracerebral hemorrhage and acute renal failure.
Key Words: Congenital leukemia; myelocytic; skin nodule