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The Korean Journal of Pathology 1987;21(2): 90-93.
Hepatic Changes Resembling the Indian Childhood Cirrhosis in an IgM anti-CMV Positive Infant.
Soo Im Choi, Chan Il Park, Ki Sup Chung
1Department of Pathology, Yonsei University, College of Medicine, Seoul, Korea.
2Department of Pediatrics, Yonsei University, College of Medicine, Seoul, Korea.
This is to describe a neonatal hepatitis with pericellular hepatic fibrosis and Mallory bodies in a sero-positive infant for IgM anti-CMV. A necropsy of the liver revealed severe heaptocellular swelling with many intracytoplasmic hyaline bodies, pronounced fibrosis of a creeping type, bile stasis with ductular proliferation, and the lack of parenchymal regeneration. These microscopical changes of the liver resembled those of Indian Childhood Cirrhosis (ICC). In the present case the patient's serum IgM anti-CMV is the only clue for the etiological diagnosis.
Key Words: Cytomegalovirus; Cirrhosis; Indian childhood cirrhosis; Mallory body
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