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The Korean Journal of Cytopathology 2008;19(1): 9-15.
doi: https://doi.org/10.3338/kjc.2008.19.1.9
Fine Needle Aspiration Cytologic Findings of Pulmonary Neuroendocrine Tumors.
Jae Soo Koh
Department of Pathology, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Science, Seoul, Korea. jskoh@kcch.re.kr
The major categories of neuroendocrine tumors of lung are typical carcinoid, atypical carcinoid, large cell neuroendocrine carcinoma, and small cell carcinoma. The histologic classification criteria of neuroendocrine tumors are well documented in the "WHO Classification of Tumors" based on mitotic figures and necrosis. Cytologic characteristics of neuroendocrine tumors are trabecular, acinar, and solid arrangement of tumor cells and occasional rosette formation. Nuclear chromatin patterns are characteristically described as "salt and pepper chromatin pattern". Many of cytologic classifications documented in the literature are before the "WHO Classification". In this review, the cytologic features of pulmonary neuroendocrine tumors are documented according to the WHO classification, and recent concepts of neuroendocrine tumors of lung are discussed.
Key Words: Lung neoplasms; Neuroendocrine tumors; Biopsy; Fine needle