Table 1.Non-neoplastic pathologic findings
Pathologic finding |
|
n (%) |
Glomerulosclerosis (global and segmental) |
0% |
10 (11.8) |
|
1-10% |
58 (68.2) |
|
11-20% |
8 (9.4) |
|
> 20% |
9 (10.6) |
Tubular atrophy |
Grade 0 (none) |
5 (5.9) |
|
Grade 1 (up to 25%) |
68 (80.0) |
|
Grade 2 (26-50%) |
9 (10.6) |
|
Grade 3 (> 50%) |
3 (3.5) |
Interstitial fibrosis |
Grade 0 (up to 5%) |
25 (29.4) |
|
Grade 1 (6-25%) |
51 (60.0) |
|
Grade 2 (26-50%) |
8 (9.4) |
|
Grade 3 (> 50%) |
1 (1.2) |
Interstitial inflammation |
Grade 0 (< 10%) |
58 (68.2) |
|
Grade 1 (10-25%) |
19 (22.4) |
|
Grade 2 (26-50%) |
5 (5.9) |
|
Grade 3 (> 50%) |
3 (3.5) |
Nephrocalcinosis |
|
11 (12.9) |
Arteriosclerosis |
Grade 0 |
8 (9.4) |
|
Grade 1 |
27 (31.8) |
|
Grade 2 |
47 (55.3) |
|
Grade 3 |
3 (3.5) |
Arteriolar hyalinosis |
|
3 (3.5) |
Table 2.The impact of pathologic findings on eGFR
Parameter |
|
Solution for fixed effects
|
|
Estimate |
Standard error |
Degree of freedom |
t-value |
Pr > |t| |
Tumour size |
|
0.2544 |
0.6896 |
59.4 |
0.37 |
0.7136 |
Percentage of global glomerulosclerosis |
|
–0.6659 |
0.2386 |
58.1 |
–2.79 |
0.0071 |
Tubular atrophy |
Grade 0 |
–9.9441 |
17.9691 |
63.7 |
–0.55 |
0.5819 |
|
Grade 1 |
–14.1515 |
15.3922 |
64.7 |
–0.92 |
0.3613 |
|
Grade 2 |
–7.0122 |
13.8371 |
60.2 |
–0.51 |
0.6142 |
|
Grade 3 |
0 |
- |
- |
- |
- |
Interstitial inflammation |
Grade 0 |
–7.2663 |
18.6642 |
60.1 |
–0.39 |
0.6984 |
|
Grade 1 |
–3.0010 |
17.9372 |
59.0 |
–0.17 |
0.8677 |
|
Grade 2 |
0 |
- |
- |
- |
- |
|
Grade 3 |
0 |
- |
- |
- |
- |
Interstitial fibrosis |
Grade 0 |
31.5260 |
31.6884 |
83.5 |
0.99 |
0.3227 |
|
Grade 1 |
32.0947 |
31.2086 |
83.4 |
1.03 |
0.3067 |
|
Grade 2 |
13.9503 |
24.4005 |
77.5 |
0.57 |
0.5692 |
|
Grade 3 |
0 |
- |
- |
- |
- |
Arteriosclerosis intimal thickness (R) |
|
0.1078 |
0.3315 |
64.9 |
0.33 |
0.7460 |
Table 3.Clinicopathologic features of patients with global glomerulosclerosis of more than 20%
Parameter |
Case No.
|
1 |
2 |
3 |
4 |
5 |
6 |
7 |
8 |
9 |
Sex |
M |
M |
M |
M |
M |
M |
M |
M |
M |
Age (yr) |
58 |
62 |
67 |
66 |
65 |
54 |
66 |
43 |
74 |
Preoperative diabetes |
Yes |
No |
No |
No |
No |
No |
Yes |
No |
No |
Preoperative hypertension |
Yes |
Yes |
Noa
|
Yes |
Yes |
No |
Yes |
No |
Yes |
Estimated glomerular filtration rate (mL/min/1.73 m2) |
|
|
|
|
|
|
|
|
|
Preoperative |
52.1 |
85.5 |
44.3 |
74.8 |
60.8 |
57.5 |
N/A |
N/A |
54.0 |
1 yr after surgery |
30.9 |
51.3 |
75.0 |
43.5 |
47.0 |
52.8 |
N/A |
N/A |
37.1 |
5 yr after surgery |
12.6 |
55.9 |
61.8 |
6.2 |
47.0 |
57.5 |
73.1 |
N/A |
N/A |
Global glomerulosclerosis (%) |
30 |
27 |
35 |
31 |
34 |
23 |
30 |
27 |
38 |
Tubular atrophy |
Mild |
Mild |
Moderate |
Mild |
Mild |
Moderate |
Mild |
Severe |
Moderate |
Interstitial inflammation |
Mild |
Mild |
Minimal |
Mild |
Mild |
Moderate |
Mild |
Severe |
Moderate |
Interstitial fibrosis |
Mild |
Mild |
Mild |
Mild |
Mild |
Moderate |
Mild |
Moderate |
Moderate |
Arteriosclerosis |
Moderate |
Severe |
Moderate |
Moderate |
Moderate |
Moderate |
Moderate |
Mild |
Moderate |
Table 4.The comparison of clinical and histologic features between genders
|
Female |
Male |
p-value |
No. of cases |
28 |
57 |
|
Age at nephrectomy (yr) |
55.3 ± 11.2 |
55.5 ± 11.0 |
.953 |
Presence of preoperative diabetes |
3 (10.7) |
4 (7.0) |
.560 |
Presence of preoperative hypertension |
10 (57.7) |
16 (28.1) |
.472 |
Tumour size (largest dimension, cm) (n = 83) |
5.4 ± 3.1 |
5.3 ± 3.3 |
.887 |
Histologic features |
|
|
|
Global glomerulosclerosis per case (%) |
4.5 ± 4.3 |
8.8 ± 10.2 |
.007 |
Global glomerulosclerosis > 20% |
0 (0) |
9 (15.8) |
.026 |
Tubular atrophy, grades 2 and 3 |
2 (7.1) |
10 (17.5) |
.196 |
Interstitial inflammation, grades 2 and 3 |
0 (0) |
8 (14.0) |
.037 |
Interstitial fibrosis, grades 2 and 3 |
0 (0) |
9 (15.8) |
.026 |
Arteriosclerosis, grades 2 and 3 |
17 (60.7) |
33 (57.9) |
.804 |
Estimated glomerular filtration rate (mL/min/1.73 m2) |
|
|
|
Preoperative (n = 69) |
94.4 ± 24.1 |
69.9 ± 14.9 |
.000 |
1 yr after surgery (n = 65) |
70.7 ± 15.8 |
53.0 ± 9.9 |
.000 |
5 yr after surgery (n = 52) |
87.6 ± 14.6 |
56.6 ± 13.9 |
.000 |