Department of Pathology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
1Department of Pathology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.
© 2013 The Korean Society of Pathologists/The Korean Society for Cytopathology
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IHC | No. of cases (%) | Age (yr) | p-value |
---|---|---|---|
EGFR(+) | 93/150 (62.7) | 61.2 | .016 |
p53(+) | 74/150 (49.3) | 53.5 | < .001 |
EGFR(+)/p53(–) | 62/150 (41.3) | 65.4 | < .001 |
EGFR(–)/p53(+) | 43/150 (28.7) | 53.8 | .019 |
EGFR(+)/p53(+) | 31/150 (20.7) | 53.09 | .126 |
EGFR(–)/p53(–) | 14/150 (9.3) | 57.9 | .075 |
IDH-1 positive | IDH-1 negative | p-value | |
---|---|---|---|
No. of cases | 16 (11.1) | 128 (88.9) | |
Age (yr) | 45.2 | 60.0 | < .001 |
Male/Female ratio | 1.33 | 0.56 | .136 |
Clinically secondary GBM | 4/4 | 0/4 | .006 |
EGFR(+) | 7/16 (43.8) | 82/128 (64.1) | .97 |
p53(+) | 14/16 (87.5) | 57/128 (44.5) | .01 |
IHC | Clinically primary GBM | Clinically secondary GBM |
---|---|---|
IDH-1(–)/EGFR(+)/p53(–) | 58 (40.2) | 0 (0) |
IDH-1(–)/EGFR(+)/p53(+) | 24 (16.6) | 0 (0) |
IDH-1(–)/EGFR(–)/p53(+) | 33 (22.9) | 0 (0) |
IDH-1(–)/EGFR(–)/p53(–) | 13 (9.0) | 0 (0) |
IDH-1(+)/EGFR(+)/p53(–) | 1 (0.6) | 0 (0) |
IDH-1(+)/EGFR(+)/p53(+) | 6 (4.1) | 0 (0) |
IDH-1(+)/EGFR(–)/p53(–) | 0 (0) | 1 (0.6) |
IDH-1(+)/EGFR(–)/p53(+) | 5 (3.4) | 3 (2.0) |
Case No. | Age | Sex | Previous Diagnosis | EGFR | p53 | IDH-1 |
---|---|---|---|---|---|---|
1 | 36 | F | Diffuse astrocytoma | – | – | + |
2 | 39 | M | Anaplastic astrocytoma | – | + | + |
3 | 45 | M | Diffuse astrocytoma | – | + | + |
4 | 56 | F | Anaplastic astrocytoma | – | + | + |
5 | 57 | F | None | – | + | + |
6 | 38 | M | None | – | + | + |
7 | 69 | F | None | – | + | + |
8 | 19 | F | None | – | + | + |
9 | 40 | M | None | – | + | + |
Sensitivity | Specificity | Accuracy | PPV | NPV | |
---|---|---|---|---|---|
EGFR(+) | 65.93 | 100.00 | 68.06 | 100.00 | 16.36 |
p53(–) | 53.33 | 88.89 | 55.56 | 98.63 | 11.27 |
IDH-1(–) | 94.07 | 100.00 | 94.44 | 100.00 | 52.94 |
EGFR(+) and p53(–) | 43.70 | 100.00 | 47.22 | 100.00 | 10.59 |
EGFR(+) or p53(–) | 90.37 | 11.11 | 85.42 | 93.85 | 7.14 |
IDH-1(–) and EGFR(+) | 60.74 | 100.00 | 63.19 | 100.00 | 14.52 |
IDH-1(–) or EGFR(+) | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 |
IDH-1(–) and p53(–) | 52.59 | 100.00 | 55.56 | 100.00 | 12.33 |
IDH-1(–) or p53(–) | 95.56 | 88.89 | 95.14 | 99.23 | 57.14 |
EGFR(+) and p53(–) and IDH-1(–) | 42.96 | 100.00 | 46.53 | 100.00 | 10.47 |
Sensitivity | Specificity | Accuracy | PPV | NPV | |
---|---|---|---|---|---|
EGFR(–) | 100.00 | 65.93 | 68.06 | 16.36 | 100.00 |
p53(+) | 88.89 | 53.33 | 55.56 | 11.27 | 98.63 |
IDH-1(+) | 100.00 | 94.81 | 95.14 | 56.20 | 100.00 |
EGFR(–) and p53(+) | 88.89 | 75.56 | 76.39 | 19.51 | 99.03 |
EGFR(–) or p53(+) | 100.00 | 43.70 | 47.22 | 10.59 | 100.00 |
IDH-1(+) and EGFR(–) | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 |
IDH-1(+) or EGFR(–) | 100.00 | 60.74 | 63.19 | 14.52 | 100.00 |
IDH-1(+) and p53(+) | 88.89 | 95.56 | 95.14 | 57.14 | 99.23 |
IDH-1(+) or p53(+) | 100.00 | 53.33 | 56.25 | 12.50 | 100.00 |
EGFR(–) and p53(+) and IDH-1(+) | 88.89 | 100.00 | 99.31 | 100.00 | 99.26 |
EGFR, epidermal growth factor receptor; IHC, immunohistochemistry.
Values are presented as number (%). IDH-1, isocitrate dehydrogenase 1; GBM, glioblastoma; EGFR, epidermal growth factor receptor.
Values are presented as number (%). IDH-1, isocitrate dehydrogenase 1; EGFR, epidermal growth factor receptor; IHC, immunohistochemistry; GBM, glioblastoma.
EGFR, epidermal growth factor receptor; IDH-1, isocitrate dehydrogenase 1; F, female; M, male.
Values are presented as percentage. PPV, positive predictive value; NPV, negative predictive value; EGFR, epidermal growth factor receptor; IDH-1, isocitrate dehydrogenase 1.
Values are presented as percentage. PPV, positive predictive value; NPV, negative predictive value; EGFR, epidermal growth factor receptor; IDH-1, isocitrate dehydrogenase 1.