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The Korean Journal of Cytopathology 2000;11(2): 103-108.
Pulmonary Alveolar Proteinosis: A Case Report with Diagnostic Features in Bronchoalveolar Lavage Specimen .
Seung Yeon Ha, Hyuni Cho, Young Ha Oh
Department of Pathology, Gachon Medical School, Gil Medical Center, Incheon, Korea. syha@ghil.com
ABSTRACT
Pulmonary alveolar proteinosis(PAP) is a rare disease in which the alveolar spaces are filled with an eosinophilic, PAS-positive material, whereas the interstitial architecture of the lung usually remains unaffected. Although a definitive diagnosis is usually made by an open lung biopsy, bronchoalveolar lavage(BAL) cytology may play a decisive role in the diagnosis and therapy of these patients and may spare a patient a more invasive diagnostic procedure. The author presents a patient in whom BAL cytology specimen contained the characteristic globules of amorphous proteinaceous PAS-positive material accompanied by background of rare macrophages and inflammatory cells. Ultrastructural study using BAL specimen can confirm the diagnosis of PAP.
Key Words: Pulmonary alveolar proteinosis; Bronchoalveolar lavage; Ultrastructure
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