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JPTM > Volume 45(6); 2011 > Article
The Korean Journal of Pathology 2011;45(6): 644-649.
doi: https://doi.org/10.4132/KoreanJPathol.2011.45.6.644
A Cutaneous Myoepithelial Carcinoma Arising in a Papillary Eccrine Adenoma.
Ji Han Jung, Soyoung Im, Seok Jin Kang, Gyong Moon Kim, Ki Taik Han, Jin Young Yoo, Chang Suk Kang
1Department of Hospital Pathology, The Catholic University of Korea College of Medicine, Seoul, Korea. jinyyoo@catholic.ac.kr
2Department of Dermatology, The Catholic University of Korea College of Medicine, Seoul, Korea.
3Department of Plastic and Reconstructive Surgery, The Catholic University of Korea College of Medicine, Seoul, Korea.
ABSTRACT
Cutaneous myoepithelial neoplasms and papillary eccrine adenomas (PEA) are rare conditions. Malignant tumors within a PEA are even rarer, with only one case reported to date. Herein, we present an extremely rare case of a cutaneous myoepithelial carcinoma arising in a PEA in a 70-year-old man presenting a solid mass in the left buttock. Histopathologically, most of the resected tumor revealed features consistent with the diagnosis of PEA. Some small nests and nodules were intermixed with the PEA and were present adjacent to the PEA. The tumor cells of nests and nodules showed ovoid to spindle shaped nuclei and slightly eosinophilic cytoplasm. Immunohistochemically, they were positive for both epithelial and myogenic markers, consistent with myoepithelioma. An inguinal lymph node with a metastatic lesion showed the same findings of myoepithelioma despite inconspicuous atypia. Our case showed malignant transformation of the myoepithelial cells at the outermost layers of the PEA.
Key Words: Skin; Myoepithelial carcinoma; Papillary eccrine adenoma