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The Korean Journal of Pathology 2011;45(4): 437-440.
doi: https://doi.org/10.4132/KoreanJPathol.2011.45.4.437
Liquid-Based Pap Smear Findings of Uterine Cervical Lymphoma: Three Cases Report.
Jiyoung Kim, Hyesun Kim, Sung Ran Hong, Yi Kyeong Chun, Hy Sook Kim
Department of Pathology, Cheil General Hospital, KwanDong University College of Medicine, Seoul, Korea. hysook.kim@cgh.co.kr
Malignant lymphoma of the uterine cervix is rarely diagnosed by cytology because it presents as a subepithelial mass. We report three cases of diffuse large B-cell lymphoma in the uterine cervix with a description of liquid-based pap smear (LBP) findings. All patients were presented with cervical masses, but a suspicion of malignant lymphoma was made in only one case by preoperative LBP. The LBP of two cases showed several atypical lymphoid cells in a clear background. The other case revealed numerous atypical lymphoid cells in a necrotic background. Most tumor cells had an increased N/C ratio, round but focally irregular nuclei, coarse chromatin, and prominent nucleoli. Nuclear blebing, dimpling, and multi-lobulation were also found. Diagnosis of malignant lymphoma by LBP is usually more difficult than by conventional techniques, because of a sparse numbers of cells and the lack of necrotic background. However, well preserved morphological features and a better resolution of nuclear details could be the benefits of LBP.
Key Words: Cervix; Lymphoma; Liquid-based cytology; Surepath