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JPTM > Volume 45(4); 2011 > Article
The Korean Journal of Pathology 2011;45(4): 423-427.
doi: https://doi.org/10.4132/KoreanJPathol.2011.45.4.423
Primary Hepatic Neuroblastoma: A Case Report.
Geunyoung Jung, Jihun Kim
Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea. jihunkim@amc.seoul.kr
ABSTRACT
Neuroblastoma is a malignant tumor of primordial neural crest origin. It usually develops along the sympathetic nervous system, such as the adrenal glands or paramedian sympathetic chain and metastasizes to the liver most frequently. However, a primary hepatic neuroblastoma has not been reported yet. Here, we report a case of 29-year-old woman who presented with a solitary hepatic mass. Grossly, the mass was large, creamy, rubbery firm, and showed focal hemorrhage and central cavitation. Microscopically, the tumor cells were arranged in small nests of spindle to ovoid cells with abundant neuropil. The neuroblastic nature of the tumor was confirmed by immunohistochemistry and electron microscopy. No extrahepatic mass was found, despite a thorough systemic survey such as chest and abdominopelvic computed tomography (CT) scans and a whole body positron emission tomography-CT study. To the best of our knowledge, this is the first report of a bona fide primary hepatic neuroblastoma.
Key Words: Neuroblastoma; Liver neoplasms; Microscopy, electron; Adult