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Association of CD57+ Natural Killer Cells with Better Overall Survival in DLBCL Patients.
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HOME > J Pathol Transl Med > Volume 45(4); 2011 > Article
Original Article Association of CD57+ Natural Killer Cells with Better Overall Survival in DLBCL Patients.
Jeong Hyeon Lee, Yoon Jin Kwak, Chul Hwan Kim, Insun Kim
Journal of Pathology and Translational Medicine 2011;45(4):361-370
DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.4.361
Department of Pathology, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Korea. iskim@korea.ac.kr
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BACKGROUND
Malignant tumor cells may evoke the innate and adaptive immune systems. Various immune cells are involved in this immune reaction, and tumor infiltrating lymphocytes, macrophages, natural killer (NK) cells are associated with patient prognosis for solid tumors.
METHODS
Seventy-eight patients who were diagnosed with diffuse large B cell lymphoma (DLBCL) between 2001 and 2009 were selected. CD57+ NK cells, CD68+ tumor associated macrophages (TAMs), and CD4+ and CD8+ T cells were evaluated in tissue sections using immunohistochemical staining and compared with clinical parameters including age, gender, performance status, clinical stage, serum lactic dehydrogenase level, number of extranodal sites, international prognostic index score, chemotherapy response, and survival.
RESULTS
Patients with high numbers of CD57+ NK cells had a significantly higher overall survival rate than patients with low numbers of CD57+ NK cells. However, no significant difference was observed between the number of CD57+ NK cells and other prognostic parameters. The number of CD68+ TAMs and CD4+ or CD8+ T cells was not significantly correlated with prognostic factors in patients with DLBCL.
CONCLUSIONS
An evaluation of tumor infiltrating CD57+ NK cells is recommended as a prognostic indicator in patients with DLBCL.

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