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JPTM > Volume 45(1); 2011 > Article
The Korean Journal of Pathology 2011;45(1): 101-105.
doi: https://doi.org/10.4132/KoreanJPathol.2011.45.1.101
Langerhans Cell Sarcoma Arising in a Lymph Node: A Case Report and Review of the Literature.
Dong Wook Kang, Hyun Jin Son, Tae Hwa Baek, Hye Kyung Lee, Joo Ryung Huh, Joo Heon Kim, Mee Ja Park
1Department of Pathology, Eulji University School of Medicine, Daejeon, Korea. shjpathol@eulji.ac.kr
2Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
ABSTRACT
We report a case of Langerhans cell sarcoma presented as a solitary mass in the left supraclavicular area in a 31-year-old woman. Computed tomography revealed a relatively well-defined and lightly enhancing mass in the left supraclavicular area, measuring 5.5x4.5x3.2 cm. Excision was subsequently performed. Microscopically, the specimen consisted of an enlarged and partially effaced lymph node. Nests of different size composed of atypical tumor cells were located in the paracortex and the medulla of the lymph node. The tumor cells exhibited abundant eosinophilic or clear cytoplasm and displayed marked nuclear atypia and increased mitotic figures. Infiltration of many eosinophils was identified in the periphery and between the tumor cells. The tumor cells were reactive for CD1a and S100 protein. Ultrastructually, they were found to have Birbeck granules in the cytoplasm.
Key Words: Langerhans cell sarcoma; Lymph nodes; CD1a antigen