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JPTM > Volume 45(0); 2011 > Article
The Korean Journal of Pathology 2011;45(Suppl 1): S84-S88.
doi: https://doi.org/10.4132/KoreanJPathol.2011.45.S1.S84
Osteoclast-like Giant Cell Tumor of the Parotid Gland Accompanied with Carcinoma ex Pleomorphic Adenoma.
Mi Jung Kwon, Eun Sook Nam, Seong Jin Cho, Hyung Sik Shin, Ji Hyun Kwon, Young Soo Rho
1Department of Pathology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea.
2Department of Pathology, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea. esnam2003@yahoo.co.kr
3Department of Otorhinolaryngology-Head and Neck Surgery, Ilsong Memorial Institute Head and Neck Cancer Center, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.
ABSTRACT
The origin of osteoclast-like giant cell tumor (OGCT) of the salivary gland has been debated because the prototypic cells of osteoclast-like cells and mononuclear stromal cells are largely unexplained in this gland. Bone marrow-derived CD14+ and CD45+ monocyte-derived multipotential cells (CD14+/CD45+ MOMC) may be one of the possible origins of OGCTs of salivary glands, which have never been explored in salivary OGCTs. We present a case of OGCT accompanied with carcinoma ex pleomorphic adenoma in the parotid gland of a 67-year-old Korean female. The tumor presented as a rapidly growing cervical mass comprising a central area of carcinoma ex pleomorphic adenoma and a peripheral circumferential area of OGCT. The immunohistochemical staining pattern was phenotypically consistent with bone marrow-derived CD14+/CD45+ MOMC. This case is the first report of a salivary OGCT in Korea.
Key Words: Giant cell tumor; Parotid gland; Mixed tumor, malignant; Osteoclasts; Monocytes