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JPTM > Volume 45(0); 2011 > Article
The Korean Journal of Pathology 2011;45(Suppl 1): S62-S65.
doi: https://doi.org/10.4132/KoreanJPathol.2011.45.S1.S62
Bilateral Frontal Polymicrogyria: An Autopsy Case Report.
Yi Kyeong Chun, Jong Sun Choi, Je G Chi
1Department of Pathology, Cheil General Hospital and Women's Healthcare Center, Kwandong University College of Medicine, Seoul, Korea. ykcmd@naver.com
2Department of Pathology, Dongguk University College of Medicine, Goyang, Korea.
3Department of Pathology, Seoul National University College of Medicine, Seoul, Korea.
ABSTRACT
Bilateral frontal polymicrogyria is a recently recognized syndrome characterized by symmetric polymicrogyria of both frontal lobes that presents with delayed motor and language development, spastic quadriparesis, and variable mental retardation. However, the postmortem findings of this syndrome are not fully elaborated. Here we describe an autopsy case of bilateral frontal polymicrogyria in a male fetus delivered at 22 weeks gestation due to extensive chorioamnionitis. The microscopic findings included a thinned cortical plate with fair neuronal maturation. There were no signs of neuronal damage and the white matter was unremarkable.
Key Words: Frontal lobe; Malformations of cortical development; Chorioamnionitis; Neuronal migration disorders
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