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JPTM > Volume 45(0); 2011 > Article
The Korean Journal of Pathology 2011;45(Suppl 1): S53-S57.
doi: https://doi.org/10.4132/KoreanJPathol.2011.45.S1.S53
In Situ Follicular Lymphoma Developed after Hodgkin Lymphoma.
Ho Sung Park, Sang Jae Noh, Jae Yong Kwak, Eun Kee Song, Myung Hee Sohn, Ho Lee, Woo Sung Moon, Kyu Yun Jang
1Department of Pathology, Chonbuk National University Medical School, Jeonju, Korea. kyjang@chonbuk.ac.kr
2Department of Internal Medicine, Chonbuk National University Medical School, Jeonju, Korea.
3Department of Nuclear Medicine, Chonbuk National University Medical School, Jeonju, Korea.
4Forensic Medicine, Research Institute of Clinical Medicine and Institute for Medical Sciences, Chonbuk National University Medical School, Jeonju, Korea.
ABSTRACT
In situ follicular lymphoma is a newly defined entity among the lymphoid neoplasms and is defined as architecturally normal-appearing lymph nodes and other lymphoid tissues that have one or more follicles that demonstrate bcl-2 overexpressing centrocytes and centroblasts, with or without a monomorphic cytologic appearance suggestive of follicular lymphoma. Here we present a case of in situ follicular lymphoma diagnosed during the follow-up after a complete response to the treatment of lymphocyte-rich classical Hodgkin's lymphoma. In our case, because only a few germinal centers contained bcl-2 overexpressing cells, we missed the diagnosis of in situ follicular lymphoma in the initial histological examination. We could establish the diagnosis only after performing bcl-2 immunostaining in the sequential biopsy. Therefore, we recommend that careful histological examination along with bcl-2 immunostaining is needed in patients with suspicious clinical findings.
Key Words: Lymphoma; Bcl-2 protein; Preneoplastic conditions
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