Warning: mkdir(): Permission denied in /home/virtual/lib/view_data.php on line 81

Warning: fopen(upload/ip_log/ip_log_2024-03.txt): failed to open stream: No such file or directory in /home/virtual/lib/view_data.php on line 83

Warning: fwrite() expects parameter 1 to be resource, boolean given in /home/virtual/lib/view_data.php on line 84
Significance of Osteopontin Expression in the Progression of Human Focal Segmental Glomerulosclerosis.
Skip Navigation
Skip to contents

J Pathol Transl Med : Journal of Pathology and Translational Medicine

OPEN ACCESS
SEARCH
Search

Articles

Page Path
HOME > J Pathol Transl Med > Volume 44(5); 2010 > Article
Original Article Significance of Osteopontin Expression in the Progression of Human Focal Segmental Glomerulosclerosis.
Ghil Suk Yoon, Tae Sook Kim
Journal of Pathology and Translational Medicine 2010;44(5):462-468
DOI: https://doi.org/10.4132/KoreanJPathol.2010.44.5.462
1Department of Pathology, Kyungpook National University School of Medicine, Daegu, Korea.
2Department of Pathology, Inha University School of Medicine, Incheon, Korea. tskim@inha.ac.kr
  • 3,121 Views
  • 17 Download
  • 1 Crossref
  • 1 Scopus

BACKGROUND
Osteopontin (OPN) is a cytokine related to cell-matrix adhesion and cell survival and is expressed in the distal convoluted tubules in normal adult kidneys. Only one in vitro study has investigated the role of OPN in mechanically stretched podocytes and their actin cytoskeleton rearrangement.
METHODS
Glomerular OPN expression was investigated in biopsies from patients with human idiopathic focal segmental glomerulosclerosis (FSGS) (n = 25) and in normal renal biopsies (n = 16) by immunohistochemistry.
RESULTS
OPN was expressed in the podocytes from patients with FSGS. OPN expression increased in podocytes from both non-sclerotic hypertrophic and sclerotic glomerular tufts in patients with FSGS compared to the podocytes in normal controls.
CONCLUSIONS
The results suggest that OPN plays a role in the early adaptive response of podocytes to the increased mechanical load caused by glomerular hypertrophy preceding FSGS. OPN was involved in cell-matrix adhesion and influenced the detachment delay of podocytes from the glomerular basement membrane and apoptosis.

Related articles

J Pathol Transl Med : Journal of Pathology and Translational Medicine