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The Korean Journal of Pathology 2010;44(3): 284-294.
doi: https://doi.org/10.4132/KoreanJPathol.2010.44.3.284
Immunohistochemical Array for Clear Cell Type Mucoepidermoid Carcinoma.
Yeon Sook Kim, Sang Shin Lee, Ji Yong Song, Eun Cheol Kim, Suk Keun Lee
1Department of Dental Hygiene, Cheongju University College of Dentistry, Cheongju, Korea.
2Department of Oral Pathology, Gangneung-Wonju National University College of Dentistry, Gangneung, Korea. sklee@kangnung.ac.kr
3Department of Oral & Maxillofacial Pathology, Wonkwang University College of Dentistry, Iksan, Korea.
BACKGROUND: The protein expression profile of clear cell type mucoepidermoid carcinoma (MEC) is not well known. METHODS: We examined a case of clear cell type MEC by immunohistochemical (IHC) array using 59 antibodies against oncoproteins, proliferation-related proteins, apoptosis-related proteins, growth factor-related proteins, angiogenesis-related proteins, and matrix proteins. RESULTS: MEC tumor cells showed 40 to 60% more expression of BCL-2 and cyclin-dependent kinase 4 than normal gingival tissue, and 20-40% more expression of BCL-2-associated agonist of cell death, deleted in malignant brain tumors 1, E-cadherin, eIF5A, hypoxia-inducible factor, vimentin, and Wnt-1. Expression of other proteins, including p53, epidermal growth factor receptor, proliferating cell nuclear antigen, survivin, carcinoembryonic antigen, beta-catenin, poly-ADP ribose-polymerase, etc. were relatively weak in MEC tumor cells. CONCLUSIONS: The IHC array for our MEC contained strong oncogenic signals involving Wnt-1/adenomatous polyposis coli, tumor necrosis factor a/signal transducer and activator of transcription 3/BCL-2, and pAKT pathways, signals that could result in the prolonged survival of clear tumor cells.
Key Words: Oncogenes; Immunohistochemistry; Array