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The Korean Journal of Pathology 2010;44(3): 252-258.
doi: https://doi.org/10.4132/KoreanJPathol.2010.44.3.252
Prognostic Value of Phosphorylated Akt and Survivin Expression in Gastric Adenocarcinoma.
Soong Lee, Yun Cheol Kim, Hyeon Min Lee, Ki Sang Lee, Byung Chul Shin, Hyung Seok Kim, Jae Hyuk Lee, Chang Soo Park, Kyung Hwa Lee
1Department of Internal Medicine, Seonam University College of Medicine, Namwon, Korea.
2Department of Forensic Medicine, Chonnam National University Medical School, Gwangju, Korea.
3Center for Biomedical Human Resources (BK-21), Chonnam National University Medical School, Gwangju, Korea.
4Department of Pathology, Chonnam National University Medical School, Gwangju, Korea. mdkaylee@gmail.com
BACKGROUND: pAkt (the phosphorylated form of the proto-oncogene protein c-akt) and survivin (human BIRC5 protein) are candidate apoptosis-related molecules that may be responsible for cancer progression. The aim of this study was to determine the expression of pAkt and survivin in malignant stomach neoplasm, and their value as prognostic indicators of cancer. METHODS: The expression of pAkt and survivin in 144 cases of gastric cancer was detected by immunohistochemistry and compared with established clinicopathological parameters and prognosis of this disease. RESULTS: Expression of pAkt showed significant correlations with depth of invasion, lymph node and distant metastasis, as well as the stage (p < 0.05 for all three correlations), but not with the Lauren classification. Survivin expression closely correlated with histological type, Lauren classification, depth of invasion, metastasis, and stage (p < 0.05 for all). The overall survival of patients with pAkt/survivin expression was inferior to that of patients with loss of pAkt/survivin expression. Cox multivariate analysis demonstrated a significant correlation between stage (p = 0.04), survivin expression (p = 0.02), and prognosis. CONCLUSIONS: Patients with pAkt/survivin expression in gastric cancer are at increased risk of cancer-related mortality via the apoptosis resistance pathway. Expression of pAkt and survivin could be used as a prognostic indicator for gastric cancer.
Key Words: Proto-oncogene proteins c-akt; BIRC5 protein, human; Stomach neoplasms; Apoptosis