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JPTM > Volume 44(2); 2010 > Article
The Korean Journal of Pathology 2010;44(2): 199-203.
doi: https://doi.org/10.4132/KoreanJPathol.2010.44.2.199
A Case of Paraduodenal Pancreatitis and Immunohistochemical Analysis.
Mi Jung Kwon, Eun Sook Nam, Seong Jin Cho, Hyung Sik Shin, Joo Seop Kim, Doo Jin Kim
1Department of Pathology, Samsung Medical Center, Sungkyunkwan University College of Medicine, Seoul, Korea.
2Department of Pathology, Kangdong Sacred-Heart Hospital, Hallym University College of Medicine, Seoul, Korea. esnam2003@yahoo.co.kr
3Department of Surgery, Kangdong Sacred-Heart Hospital, Hallym University College of Medicine, Seoul, Korea.
ABSTRACT
Paraduodenal pancreatitis (PP) is a rare, distinct form of chronic pancreatitis, and it is related to alcohol abuse in middle-aged men. A 36-year-old man with a history of chronic recurrent pancreatitis for 4 years and alcohol abuse for 15 years presented with abdominal pain. Computed tomography revealed a multilocular cystic mass 3.2 x 3 x 3 cm in size and it was located within the muscular layer of the duodenal wall. The cysts were lined by a single layer of eosinophilic cuboidal epithelial cells that stained positively for mucin (MUC)1, MUC6, cytokeratin (CK)7 and CK19 and they stained negatively for MUC2, MUC5AC and CK5/6. Mild, chronic inflammatory reaction around the cystic wall, Brunner's gland hyperplasia and several clusters of heterotopic pancreatic tissue were noted. We report here on a case of PP and we demonstrated that the pancreatitis was of pancreatic ductal cell origin according to the MUC and CK expression patterns we observed on the immunohistochemical analysis.
Key Words: Pancreatitis, chronic; Pancreatic ducts; Cysts