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JPTM > Volume 43(4); 2009 > Article
The Korean Journal of Pathology 2009;43(4): 368-373.
doi: https://doi.org/10.4132/KoreanJPathol.2009.43.4.368
Morphological Features of Metastatic Gastrointestinal Stromal Tumors after Gleevec Treatment: Two Cases Report.
Joon Hyuk Choi, Young Kyung Bae, Sun Kyo Song, Hong Jin Kim, Min Chul Shim, Kyung Hee Lee
1Department of Pathology, Yeungnam University College of Medicine, Daegu, Korea. joonhyukchoi@ynu.ac.kr
2Department of Surgery, Yeungnam University College of Medicine, Daegu, Korea.
3Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, Korea.
ABSTRACT
We report two patients with metastatic gastrointestinal stromal tumors (GISTs) with a focus on the morphological features related to Gleevec treatment. In case 1, a 50-year-old woman presented with a 1.8 cm metastatic GIST in the liver after resection of a gastric GIST. Majority of the metastatic tumor showed fibrosis and hyalinization after 8 weeks of Gleevec treatment. CD117-positive cells were present in approximately 1% of the overall tumor. In case 2, a 2 cm and 14 cm metastatic liver masses were found in a 54-year-old man who had a rectal GIST. After 4 weeks of Gleevec treatment, metastatic tumors showed a decrease in size on CT scan. The metastatic tumors showed a decrease in number of tumor cells. The hemorrhage, cystic changes, necrosis, and fibrosis made up approximately 90% of the tumor. The morphological features related to Gleevec treatment are important for correct diagnosis and evaluation of tumor response and prognosis.
Key Words: Gastrointestinal stromal tumor; Gleevec; Liver; Metastasis; Morphology