| Home | E-Submission | Sitemap | Contact Us |  
top_img
JPTM > Volume 43(4); 2009 > Article
The Korean Journal of Pathology 2009;43(4): 342-350.
doi: https://doi.org/10.4132/KoreanJPathol.2009.43.4.342
Prevalence and Genotype Distribution of Cervical Human Papillomavirus DNA in Korean Women: A Multicenter Study.
Sung Ran Hong, In Sun Kim, Dong Won Kim, Mi Jin Kim, Ae Ree Kim, Young Ok Kim, Hye Sun Kim, Seo Hee Rha, Gyeong Sin Park, Yong Koo Park, Yong Wook Park, Ho Sung Park, Kwang Sun Suh, Jin Hee Sohn, Mi Kyung Shin, Hoon Kyu Oh, Ki Jung Yun, Hye Kyoung Yoon, Shi Nae Lee, Ah Won Lee, Hyo Jin Lee, Hyun Yee Cho, Chan Choi, Woon Won Jung
1Department of Pathology, Kwandong University Cheil General Hospital & Women's Healthcare Center, Seoul, Korea.
2Department of Pathology, Korea University Anam Hospital, Seoul, Korea. iskim@korea.ac.kr
3Department of Pathology, Soonchunhyang University Hospital, Seoul, Korea.
4Department of Pathology, Yeungnam University College of Medicine, Daegu, Korea.
5Department of Pathology, Korea University Guro Hospital, Seoul, Korea.
6Department of Pathology, Kosin University College of Medicine, Busan, Korea.
7Department of Pathology, Dong-A University College of Medicine, Busan, Korea.
8Department of Pathology, Catholic University, St. Mary's Hospital, Seoul, Korea.
9Department of Pathology, Kyung Hee University Medical Center, Seoul, Korea.
10Department of Pathology, Hanyang University Kuri Hospital, Guri, Korea.
11Department of Pathology, Chonbuk National University College of Medicine, Jeonju, Korea.
12Department of Pathology, Chungnam National University College of Medicine, Daejeon, Korea.
13Department of Pathology, Sunghyunkwan University Kangbuk Samsung Medical Center, Seoul, Korea.
14Department of Pathology, Hallym University, Gangnam Sacred Heart Hospital, Seoul, Korea.
15Department of Pathology, Daegu Catholic University Medical Center, Daegu, Korea.
16Department of Pathology, Wonkwang University College of Medicine, Iksan, Korea.
17Department of Pathology, Inje University Busan Paik Hospital, Busan, Korea.
18Department of Pathology, Ewha Womans University College of Medicine, Seoul, Korea.
19Department of Pathology, Catholic University, Gangnam St. Mary's Hospital, Seoul, Korea.
20Department of Pathology, National Police Hospital, Seoul, Korea.
21Department of Pathology, Medical School Gil Medical Center, Incheon, Korea.
22Department of Pathology, Chonnam National University Hwasun Hospital, Hwasun, Korea.
23Department of Clinical Pathology, College of Health Science, Korea University, Seoul, Korea.
ABSTRACT

Background:
DNA prevalence and type distribution of human papillomavirus (HPV) varies geographically. We investigated HPV prevalence and type distribution in Korean women using the MyHPV DNA chip testing.
Methods:
A total of 2,368 women from five regions of the country underwent Pap smear examination and MyHPV chip testing.
Results:
Overall HPV positivity was 15.8% and 78.4% in women with normal and abnormal cytology, respectively. High-risk HPV infection was strongly correlated with cytological atypia. In women with abnormal cytology, the five most common HPV types were 16, 58, 18, 52, and 56/53, and HPV16 was significantly the most common type in most geographical regions. After HPV16, HPV58, and 52 were the next most frequently detected types. Women with normal cytology, in contrast, showed heterogeneity in HPV type distribution. High-grade intraepithelial lesions infected with HPV16, 18, 31 or 45 are more likely to progress to carcinoma.
Conclusions:
The HPV chip test can provide useful data regarding HPV positivity and type. The most common HPV type in Korean women with abnormal cytology is HPV16, with HPV58 and 52 being frequently present. Our data may have important implications for vaccination programs and the development of cervical screening.
Key Words: Uterine cervix; Human papillomavirus; DNA chips; Papanicolaou test; South Korea
TOOLS
PDF Links  PDF Links
Full text via DOI  Full text via DOI
Download Citation  Download Citation
CrossRef TDM  CrossRef TDM
  E-Mail
Share:      
METRICS
14
Crossref
9
Scopus
2,148
View
36
Download
Related article