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JPTM > Volume 43(4); 2009 > Article
The Korean Journal of Pathology 2009;43(4): 321-328.
doi: https://doi.org/10.4132/KoreanJPathol.2009.43.4.321
Expression of p63 and its Isoform, deltaNp63, in Non-Small Cell Lung Carcinoma.
Ick Doo Kim, Dong Hoon Shin, Kyung Un Choi, Do Youn Park, Gi Yeong Huh, Mee Young Sol, Min Ki Lee, Young Dae Kim, Chang Hun Lee
1Department of Pathology, School of Medicine, Pusan National University, Busan, Korea. cnlee@pusan.ac.kr
2Department of Internal Medicine, School of Medicine, Pusan National University, Busan, Korea.
3Department of Thoracic Surgery, School of Medicine, Pusan National University, Busan, Korea.
4Medical Research Institute, Pusan National University, Busan, Korea.
ABSTRACT
BACKGROUND: Several studies have been conducted on the role of the p63 gene family in non-small cell lung carcinoma (NSCLC). Nevertheless, the role of these genes in the development and progression of NSCLC remains controversial. This study was designed to examine the expression and clinicopathologic significance of the p63 family in NSCLC. METHODS: Immunohistochemical staining was performed on 92 cases of NSCLC (47 squamous cell carcinomas [SqCCs] and 45 adenocarcinomas [ACs]) using tissue microarray blocks. The results were analyzed and correlated with clinicopathologic data. RESULTS: The expression of delta Np63 (Delta Np63) was elevated in SqCC (39/47), but not in AC (2/45; p<0.01). Both p63 and Delta Np63 had high expression in 39 SqCCs; p63 and Delta Np63 also had a similar geomorphologic distribution in most positive tumors. The expression of Delta Np63 was correlated with histologic type, gender, pT stage, p53 expression, and p63 expression. pT and pN stages were independent factors in survival (p<0.05, respectively). CONCLUSIONS: The major p63 isoform in NSCLC, Delta Np63, had a strong correlation with p53 and p63, and was exclusively expressed in SqCC. However, our findings suggest that Delta Np63 was not an independent prognostic factor for NSCLC.
Key Words: Carcinoma, Non-small cell lung; Carcinoma, Squamous cell; DeltaNp63 protein; p63 tumor suppressor protein; Immunohistochemistry