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JPTM > Volume 43(3); 2009 > Article
The Korean Journal of Pathology 2009;43(3): 206-211.
doi: https://doi.org/10.4132/KoreanJPathol.2009.43.3.206
The Expression of Cyclooxygenase-2 and Survivin in Urinary Bladder Transitional Cell Carcinoma.
Tae Jung Jang, Kyung Seob Lee
1Department of Pathology, Dongguk University College of Medicine, Gyeongju, Korea.
2Department of Urology, Dongguk University College of Medicine, Gyeongju, Korea. taejung@mail.dongguk.ac.kr
ABSTRACT
BACKGROUND: The aim of this study was to investigate the expressions of cyclooxygenase-2 (COX-2) and survivin in bladder transitional cell carcinoma (TCC) that has different clinicopathologic characteristics, and we also wanted to determine if a relation exists between the COX-2 and survivin expressions. METHODS: The expressions of COX-2 and survivin were investigated in 80 bladder TCCs by performing immunohistochemistry. RESULTS: The normal bladder mucosa did not express COX-2 and survivin. COX-2 immunopositivity and cytoplasmic survivin immunopositivity were seen in 48% and 30% of bladder tumors, respectively. The expressions of COX-2 and survivin were closely related to the differentiation, depth and recurrence of bladder TCC, and there was a significant correlation in topographic distribution of COX-2 and survivin immunopositivity. In addition, COX-2 and survivin were predominantly expressed at the invasive front of tumors. CONCLUSIONS: This data suggest that COX-2 and survivin may be involved in the progression of bladder TCC, and there is a close correlation between the expressions of COX-2 and survivin.
Key Words: Bladder cancer; Cyclooxygenase-2; Survivin