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JPTM > Volume 43(1); 2009 > Article
The Korean Journal of Pathology 2009;43(1): 79-82.
doi: https://doi.org/10.4132/KoreanJPathol.2009.43.1.79
Gastric Adenocarcinoma with Coexistent Hepatoid Adenocarcinoma and Neuroendocrine Carcinoma: A Case Report.
Aeri Kim, Sang Woon Kim, Sun Kyo Song, Young Kyung Bae
1Department of Pathology, Yeungnam University College of Medicine, Daegu, Korea. ykbae@ynu.ac.kr
2Department of Surgery, Yeungnam University College of Medicine, Daegu, Korea.
This report represents a very rare case of a gastric adenocarcinoma that was coexistent with hepatoid adenocarcinoma and neuroendocrine carcinoma. A 77-year-old man was admitted to our hospital due to a huge ulcerofungating mass identified at the proximal body of the stomach. After a pathological diagnosis of the tumor as a poorly differentiated adenocarcinoma was made, the patient underwent a total gastrectomy with lymph node dissection. Microscopically, the tumor consisted of three morphologically distinct components-tubular adenocarcinoma, hepatoid adenocarcinoma and neuroendocrine carcinoma. The hepatoid adenocarcinoma component resembled a hepatocellular carcinoma and produced alpha-fetoprotein. The neuroendocrine carcinoma component was positive for chromogranin and synaptophysin immunostains. This is an example of the diverse morphological and immunophenotypical differentiation of gastric carcinomas.
Key Words: Gastric cancer; AFP; Hepatocellular carcinoma; Neuroendocrine carcinoma