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The Korean Journal of Pathology 2008;42(6): 389-392.
Uterine Cervical Large Cell Neuroendocrine Carcinoma Concurrent with High Grade Squamous Intraepithelial Neoplasia: A Case Report.
Yun Kyung Kang, Jae Whoan Koh
1Department of Pathology, Inje University Seoul Paik Hospital, Seoul, Korea. jadepaka@hanmail.net
2Department of Obstetrics and Gynecology, Inje University Seoul Paik Hospital, Seoul, Korea.
Large cell neuroendocrine carcinoma (LCNEC) of the uterine cervix is a rare and aggressive malignancy. We report a case of uterine cervical LCNEC concurrent with high grade squamous intraepithelial neoplasia (HG-SIN). The LCNEC expressed chromogranin A and thyroid transcription factor 1 (TTF1). The HG-SIN was negative for these markers. Human papillomavirus (HPV) type 18 was positive in LCNEC whereas both type 16 and 18 were positive in HG-SIN by nested polymerase chain reaction. This case showed TTF1 positivity nonetheless diagnosed as a primary uterine cervical LCNEC confirmed by the detection of HPV genome within the tumor. It is critical to recognize LCNEC of the uterine cervix even in the small biopsy specimen because it is a distinctive clinicopathological entity with highly aggressive behavior and unfavorable outcome.
Key Words: Carcinoma, large cell; Carcinoma, neuroendocrine; Cervix uteri; Thyroid transcription factor 1; Papilloma virus, human