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The Korean Journal of Pathology 2007;41(3): 193-197.
Sclerosing Mucoepidermoid Carcinoma of the Parotid Gland: A Case Report.
Hyunchul Kim, Ju Han Lee, Eung Seok Lee, Soon Young Kwon, Taik Kun Kim, Young Sik Kim
1Department of Pathology, Korea University Ansan Hospital, Ansan, Korea. apysk@korea.ac.kr
2Department of Otolaryngology-Head and Neck Surgery, Korea University Ansan Hospital, Ansan, Korea.
3Department of Diagnostic Radiology, Korea University Ansan Hospital, Ansan, Korea.
ABSTRACT
Sclerosing mucoepidermoid carcinoma (SMEC) is a very rare tumor of the salivary gland. There have been eight cases of SMEC reported in the medical literature; this is the first reported case in Korea. A 51-year-old woman presented with a right infra-auricular mass that she had for 3 years. We performed superficial parotidectomy. Grossly, the resected parotid gland showed a well-circumscribed firm mass. Histologically, the tumor consisted of central solid or ductal tumor nests within a dense fibrous stroma surrounded by peripheral lymphoid infiltration. The tumor nests were composed of squamous, intermediate and mucin-secreting cells. However, the tumor cells lacked mitosis and nuclear anaplasia. The lymphoid cells were mostly composed of lymphocytes and plasma cells with occasional eosinophils and neutrophils. Immunohistochemically, the tumor cells were positive for high- and low- molecular weight cytokeratins, cytokeratin 7, p16INK4A, Bcl-2 and cyclin D1. The patient also underwent radiation therapy. We report here on a case of SMEC of the parotid gland along with the immunohistochemical characteristics, and we review the relevant literature.
Key Words: Mucoepidermoid carcinoma; Sclerosis; Parotid gland