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The Korean Journal of Pathology 2006;40(4): 306-310.
Sarcomatoid Carcinoma of the Pancreas: A Case Report.
Kyung Hee Kim, Dae Young Kang, Min Koo Lee, Hyeon Woong Yang, Hyun Young Han
1Department of Pathology and Molecular Medicine, Eulji University School of Medicine, Daejeon 302-799, Korea. phone330@eulji.ac.kr
2Department of Surgery, Eulji University School of Medicine, Daejeon 302-799, Korea.
3Department of Internal Medicine, Eulji University School of Medicine, Daejeon 302-799, Korea.
4Department of Radiology, Eulji University School of Medicine, Daejeon 302-799, Korea.
5Department of Pathology and Cancer Research Institute, Chungnam National University College of Medicine, Daejeon, Korea.
ABSTRACT
We report here on an unusual case of a 73-year-old Korean female with sarcomatoid carcinoma. This tumor was composed of pancreatic ductal adenocarcinoma and a malignant fibrous histiocytoma-like stroma. The CT imaging revealed a multiseptated heterogenous hypodense mass that was 15 cm in size. The mass was located in the body and tail of the pancreas, spleen and gastrosplenic area. The pathologic examination showed that the carcinomatous component was negative for vimentin, and the sarcomatous component was positive for vimentin and CD 68. The ultrastructural examination showed that both the carcinomatous and sarcomatous components had desmosomes at the cell-cell contact sites. The patient refused postoperative adjuvant chemotherapy and she died of cachexia with generalized tumor extension about 3 months later. This report presents special data that can clarify the clinicopathological features and pathogenesis of this rare neoplasm.
Key Words: Pancreas; Sarcomatoid carcinoma