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The Korean Journal of Pathology 2006;40(4): 292-296.
Ectopic Hamartomatous Thymoma: A Case Report along with a Review of the Literature Concerning the Histogenesis and New Nomenclature.
Sang Hee Seok, Dong Hyun Lee, Su Hwan Kang, Young Kyung Bae
1Department of Pathology, Yeungnam University College of Medicine, Daegu 705-717, Korea. ykbae@ynu.ac.kr
2Department of Surgery, Yeungnam University College of Medicine, Daegu 705-717, Korea.
ABSTRACT
Ectopic hamartomatous thymoma (EHT) is a rare and distinctive benign neoplasm of the lower neck. We here report on a case of EHT arising in the suprasternal area of 47-year-old male patient. The well-circumscribed mass measured 7 x 6 x 4 cm and it predominantly had a solid gray-white cut surface. Microscopically, the tumor consisted of spindle cells, epithelial nests, and mature adipose tissue. The epithelial component was arranged in anastomosing cords, solid nests and variable-sized cysts that were lined by squamous or cuboidal epithelium. The spindle cells revealed the myoepithelial immunohistochemical phenotype. There was no obvious thymic differentiation nor was any normal thymic tissue observed in our case. We think that EHT needs to be reclassified with using different nomenclature to designate its origin and histology. Further, pathologists and clinicians should be aware of the existence of this tumor in the lower neck so as not to mistake it for high-grade sarcoma or spindle cell carcinoma.
Key Words: Thymoma; Hamartoma; Branchial arch; Mixed tumor; Immunohistochemistry