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The Korean Journal of Pathology 2006;40(3): 241-244.
Juvenile Xanthogranuloma of the Nasal Cavity: A Case Report and Review of the Literature.
Jung Suk An, Sun Hee Han, Ju Han Lee, Eung Seok Lee, Heum Rye Park, Young Sik Kim
Department of Pathology, Korea University Ansan Hospital, Ansan, Korea. apysk@korea.ac.kr
ABSTRACT
Juvenile xanthogranuloma (JXG) is a benign and self-limiting non-Langerhans-cell histiocytosis that generally occurs during infancy and childhood. It develops frequently in the head and neck but is very rare in the nasal cavity. To date, only five cases of JXG in the nasal cavity have been reported. Here, we report the second case of JXG in the nasal cavity in Korea. A 19-year-old male patient presented with a protruding 1.1 cm mass in the left nasal vestibule. Histologically, a dense dermal infiltrate of histiocytes with Touton giant cells was observed. Immunohistochemically, the histiocytes tested positive for CD68 and the S-100 protein but negative for CD1a. This shows that a S-100-positive histiocytic lesion dose not exclude a diagnosis of JXG.
Key Words: Juvenile xanthogranuloma; Nasal cavity; Langerhans-cell histiocytosis