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The Korean Journal of Pathology 2006;40(2): 151-155.
Follicular Lymphoma with Monoclonal Plasma Cell Differentiation: A Case Report.
Hyun chul Kim, Young Seok Lee, Jung woo Choi, Ae ree Kim, Bom Woo Yeom, Han kyeom Kim, In sun Kim
Department of Pathology, Korea University Medical College, Seoul, Korea. iskim@korea.ac.kr
ABSTRACT
We present a case of recurrent follicular lymphoma with an extensive plasma cell component involving infra-auricular lymph nodes in a 64 year-old woman. Immunohistochemical staining showed a strongly positive reaction of the follicles with CD20, bcl-2, bcl-6, CD10 and CD21 on the first biopsy specimen. The intrafollicular and interfollicular plasma cells showed monoclonality for IgG heavy chain and lambda light chain. The histological and immunohistochemical findings in the recurrent tumor were identical with those of the original. Discussion is focused on the importance of the differential diagnosis between reactive lymphoid hyperplasia and other lymphomas having plasmacytic differentiation.
Key Words: Inflammatory myofibroblastic tumor; Inflammatory pseudotumor; ALK; Stomach