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The Korean Journal of Pathology 2006;40(2): 103-111.
Enhanced CD24 Expression in Colorectal Cancer Correlates with Prognostic Factors.
Yoon La Choi, Hua Xuan Yan, Sang Jeon Lee, Seon Mee Park, Wun Jae Kim, Hee Jin Kim, Seok Hyung Kim
1Department of Pathology, Chungbuk National University College of Medicine, Cheongju, Korea. platoshkim@chungbuk.ac.kr
2Department of Surgery, Chungbuk National University College of Medicine, Cheongju, Korea.
3Department of Internal Medicine, Chungbuk National University College of Medicine, Cheongju, Korea.
4Department of Urology, Chungbuk National University College of Medicine, Cheongju, Korea.
5Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
6Department of Laboratory Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
7Department of Pathology, Yanbian University College of Medicine, Yanji, China.
ABSTRACT
BACKGROUND: CD24 was originally described as a B cell-specific marker, however its aberrant expression in various solid tumors has recently been reported. Our objective was to determine the pattern and extent of the CD24 expression in colorectal cancer and its related lesions, and to clarify its correlation with clinico-pathological parameters and especially those associated with patients' prognoses. METHODS: A total of 307 colorectal cancers and the related lesions (150 carcinomas, 30 high-grade adenomas, 49 low-grade adenomas, 41 hyperplastic polyps, and 37 normal colorectal epithelia) were immunohistochemically analyzed by treating CD24 monoclonal antibody onto tissue embedded paraffin blocks. RESULTS: CD24 expression was very rarely observed in the normal epithelia, hyperplastic polyps, and low-grade adenomas; however, in high-grade adenomas, the CD24 expression was shown to be mildly increased in the cytoplasm (13.3%). In carcinomas, the CD24 expression was increased substantially in both the membrane (38.0%) and the cytoplasm (44.7%). The expression of CD24 in the membrane was positively correlated with tumor size (p<0.01). The CD24 expression in the cytoplasm was positively correlated with several unfavorable parameters, including a larger tumor size (p<0.01), a higher tumor grade (p<0.01), a higher rate of tumor invasion (p<0.05), and a higher pTNM stage (p<0.05). CONCLUSION: High levels of CD24 expression in the membrane and cytoplasm were characteristic in colorectal cancer, and the cytoplasmic CD24 expression was correlated with several unfavorable clinical parameters.
Key Words: CD24; Colorectal neoplasm; Immunohistochemistry