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The Korean Journal of Pathology 2005;39(2): 69-73.
S Phase Kinase Associated Protein 2 Expression in Breast Cancer and Its Prognostic Implications.
Eun Deok Chang, Eun Jung Lee, Se Jeong Oh, Chang Suk Kang
1Department of Pathology, The Catholic University of Korea, College of Medicine, Seoul, Korea. changed@catholic.ac.kr
2Department of General Surgery, The Catholic University of Korea, College of Medicine, Seoul, Korea.
ABSTRACT
BACKGROUND: S Phase Kinase Associated Protein 2 (Skp2), an F-box protein necessary for DNA replication, has recently been demonstrated to be an oncogene. The purpose of this study was to examine the Skp2 expression and to investigate its association with expressions of estrogen receptor (ER), androgen receptor (AR) and HER-2, as well as clinicopathological variables including tumor recurrence. METHODS: The expressions of Skp2, ER and AR were examined by immunohistochemistry and HER-2 amplification by chromogenic in situ hybridization (CISH) in 117 cases of breast carcinoma. RESULTS: Skp2 was expressed in 26 patients (22.2%) and was significantly correlated with tumor type (p=0.031), tumor grade (p=0.017) and ER expression (p=0.038). Twenty four (20.5%) of 117 patients had a tumor recurrence, and 6 patients (5.1%) died of multifocal metastases. Tumor recurrence was significantly correlated with histological grade (p=0.041) and lymph node status (p<0.001). CONCLUSIONS: Although Skp2 expression was statistically insignificant in association with tumor recurrence, it might be useful as a biologic predictor in breast cancer. The simple and reliable immunohistochemical assay presented in this study can be a routine part of breast cancer evaluation and may influence patient management.
Key Words: Androgen receptor; Breast cancer; Estrogen receptor; Her 2 gene; S-Phase Kinase-Associated Proteins