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The Korean Journal of Pathology 2004;38(6): 357-363.
Differential Expression of Promyelocytic Leukemia Protein in Autoimmune Liver Diseases.
Hyun Jung Kim, Jung Sun Kim, Yong Sang Lee, Young Hwa Chung, Han Joo Lee, Dong Jin Suh, Chong Jai Kim, Eunsil Yu
1Department of Pathology, University of Inje University of Medicine, Sanggye Paik Hospital, Seoul, Korea.
2Department of Pathology, University of Ulsan College of Medicine,Asan Medical Center, Seoul, Korea. esyu@amc.seoul.kr
3Department of Internal Medicine, University of Ulsan College of Medicine,Asan Medical Center, Seoul, Korea.
4Department of Pathology, Seoul National University College of Medicine, Seoul, Korea. esyu@amc.seoul.kr
ABSTRACT
BACKGROUND: Promyelocytic leukemia protein (PML) is a primary biliary cirrhosis (PBC)-specific autoantigen. Anti-PML antibody is analyzed using cultured cells with patient sera, however, PML expression has rarely been examined in liver tissues. METHODS: In the present study, PML expression was examined immunohistochemically in paraffin embedded liver needle biopsy specimens obtained from 20 cases of PBC, 10 cases of autoimmune cholangitis, 36 cases of autoimmune hepatitis and from 5 cases of noninflammatory livers. RESULTS: Variable PML immunopositivity was detected in the bile duct epithelial cells of 18 (90.0%) of 20 PBC cases and in all 10 cases (100.0%) of autoimmune cholangitis, whereas it was only present in 6 (16.7%) of 36 cases of autoimmune hepatitis (p<0.001). In contrast, hepatocyte PML immunopositivity was higher in autoimmune hepatitis (33/36 cases, 90.8%), than in PBC (10/20 cases, 50.0%) or autoimmune cholangitis (3/10 cases, 30.0%) (p<0.05). CONCLUSION: Our data indicate that the differential expression of PML is closely related to autoimmune liver diseases type, and suggest that the overexpression of PML protein in bile duct cells is associated with the development of autoantibodies in patients with PBC or autoimmune cholangitis. Furthermore, PML immunoreactivity may be useful for the diagnosis of autoimmune cholangitis and overlap syndrome.
Key Words: Autoimmune diseases; Hepatitis; Primary biliary cirrhosis; Nuclear proteins; PML protein, human
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