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The Korean Journal of Pathology 2003;37(6): 438-441.
Endometrial Mucinous Adenocarcinoma with Extensive Squamous Differentiation: A Case Report.
Ho chang Lee, Pil Gyu Hwang, Soo Youn Cho, Young S Park, In Ae Park
Department of Pathology, Seoul National University College of Medicine, Seoul, Korea. iapark@plaza.snu.ac.kr
ABSTRACT
Endometrial mucinous adenocarcinoma occurs in 1-9% of endometrial adenocarcinomas and adenocarcinoma with squamous differentiation in approximately 25%. We report a rare case of mucinous adenocarcinoma with squamous differentiation in a 53-year-old woman. Curetting biopsies of the endometrial lesion were taken twice after hormone replacement therapy, which lasted for four months. Because the squamous differentiation was so extensive, the initial diagnosis based on each curetting specimen was squamous papilloma. A total hysterectomy was performed and the tumor was revealed to be a mucinous adenocarcinoma with squamous differentiation. We subsequently discussed the pathogenesis and prognosis of this type of tumor.
Key Words: Adenocarcinoma, Mucinous; Endometrial Neoplasm; Squamous Metaplasia