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The Korean Journal of Pathology 2003;37(5): 369-372.
Silica Granuloma after Intermittent Intramuscular Injections: A Case Report.
Suk Jin Choi, Jong Im Lee, Jung Ran Kim, Tae Jung Jang, Ki Kwon Kim, Phil Hyun Chung
1Department of Pathology, Dongguk University, College of Medicine, Kyongju, Korea. pathjrk@dumc.or.kr
2Department of Orthopaedic Surgery, Dongguk University, College of Medicine, Kyongju, Korea.
ABSTRACT
Most silica-contaminated wounds of the skin heal without complications. Cutaneous silica granuloma is a poorly understood, uncommon condition resembling a sarcoidosis. We report a case of silica granuloma after intermittent intramuscular injections. A 70-year-old man presented a painless mass in his right buttock for 2 weeks. He had received intermittent intramuscular injections of antihistamine drugs due to chronic dermatitis for 30 years. The histolopathological findings showed numerous hyalinized collagenous nodules with concentric layers, and an ill-defined chronic granulomatous inflammation containing foreign material. A polarized light microscopic examination revealed birefrigent particles. The presence of silica components was confirmed by scanning electron microscopy and energy dispersive X-ray microanalysis.
Key Words: Silicon dioxide; Granuloma; Injection, Intramuscular