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The Korean Journal of Pathology 2003;37(5): 362-364.
Dedifferentiated Liposarcoma with a Peculiar Whorling Pattern: A Case Report.
Ji Shin Lee, Young Bog Kim
1Department of Pathology, Seonam Univerisy College of Medicine, Namwon, Korea. jshinlee@hanmail.net
2Department of General Surgery, Seonam Univerisy College of Medicine, Namwon, Korea.
A dedifferentiated liposarcoma is a uncommon neoplasm characterized by the coexistence of a well-differentiated liposarcoma and non-lipogenic sarcomas. A peculiar neural-like or meningothelial-like whorling pattern of dedifferentiation has recently been reported. We report a case of dedifferentiated liposarcoma with a peculiar whorling pattern in the scrotum of a 76-year-old man. Histologically, the tumor consisted of areas of a well differentiated liposarcoma admixed with areas of a morphologically non-lipogenic sarcoma. The whorls were scattered throughout the tumor. The cells in the whorls and dedifferentiated area showed a significant nuclear PCNA and p53 protein reactivity.
Key Words: Liposarcoma, dedifferentiated