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The Korean Journal of Pathology 2002;36(6): 433-439.
Suprasellar Endodermal Sinus Tumor Presenting with Tonic-Clonic Seizure: An Autopsy Case Report.
Min Jin Lee, Hea Soo Koo, Woon Sup Han, Sun Hee Sung, Yong Jae Kim, Hye Young Choi
1Department of Pathology, Ewha Womans University, College of Medicine Seoul, Korea. heasoo@ewha.ac.kr
2Department of Neurology, Ewha Womans University, College of Medicine Seoul, Korea.
3Department of Radiology, Ewha Womans University, College of Medicine Seoul, Korea.
ABSTRACT
We report the clinical course and autopsy findings of a 19-year-old girl with endodermal sinus tumor involving the thalamus, hypothalamus, and basal ganglia. The patient initially had tonic-clonic seizures with abnormal signal involving the right hippocampus, amygdala, basal ganglia, putamen, and dentate gyrus. The signal intensity of the posterior pituitary on T1-weighted images was decreased at the time of admission, which was not associated with clinical symptoms of diabetes insipidus (DI). A huge tumor mass as well as central DI developed within 10 months. The postmortem examination showed gliosis with calcification involving the right basal ganglia, internal capsule, and white matter, in addition to a tumor mass involving the thalamus, hypothalamus, and basal ganglia. Dissemination of tumor cells in the leptomeninges and the gliotic area and hydrocephalus were also noted.
Key Words: Brain Neoplasms; Endodermal Sinus Tumor; Epilepsy; Tonic; Clonic