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The Korean Journal of Pathology 2002;36(4): 199-204.
Tissue Array Method for Large Scale Clinicopathologic Study.
Woo Ho Kim
Department of Pathology, Seoul National University College of Medicine, Seoul, Korea. woohokim@snu.ac.kr
Tissue array consists of a slide containing hundreds or thousands of cases, making this method useful for rapid analysis of molecular markers in a large number of cases. The method significantly facilitates and accelerates the clinicopathologic analysis of cancer. To maximize the efficacy of the tissue array method in pathologic study, the pros and cons of this method should be understood. In this review, the history and a detailed method of tissue array production is described, emphasizing the advantage of the large core size (2.0 mm). Some methological points, including slide storage, microtoming, core size, reliability, and data analysis, are discussed.
Key Words: Methods-Immunohistochemistry