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The Korean Journal of Pathology 2001;35(5): 440-443.
Small Cell Carcinoma of the Ovary, Hypercalcemic Type, Large Cell Variant.
Jong Sil Lee, Jong Hak Lee, Yu Kyung Kim, Sun Hoo Park, Gyung Hyuck Ko
Department of Pathology and Obstetrics and Gynecology, Gyeongsang National University College of Medicine, Jinju 660-751, Korea. gyunghko@gshp.gsnu.ac.kr
We report the clinical and pathological features, including the immunohistochemical and electron microscopic findings, of a case of hypercalcemic type, large cell variant, ovarian small cell carcinoma. A 44-year-old woman complained of abdominal pain and dysmenorrhea. A mass on the left ovary was detected by computer tomographic scan. A total hysterectomy with bilateral salpingo-oophorectomy was done. Histologically, the tumor was predominantly composed of large cells with abundant eosinophilic cytoplasm and prominent nucleoli. Mucin-containing cells and myxoid stroma were also present. Typical follicle-like spaces with lined by small, closely packed epithelial cells with scanty cytoplasm were occasionally seen. No dense core granules were identified on electron microscopic examination.
Key Words: Ovary; Carcinoma; Small cell; Hypercalcemia